You can:
Name | Hydroxycarboxylic acid receptor 2 |
---|---|
Species | Homo sapiens (Human) |
Gene | HCAR2 |
Synonym | G protein-coupled receptor 109A PUMAG Nicotinic acid receptor Nic1 Niacr1 [ Show all ] |
Disease | Type 2 diabetes Hyperlipidaemia Major depressive disorder Cardiovascular disorder Atherosclerosis [ Show all ] |
Length | 363 |
Amino acid sequence | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP |
UniProt | Q8TDS4 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q8TDS4 |
3D structure model | This predicted structure model is from GPCR-EXP Q8TDS4. |
BioLiP | N/A |
Therapeutic Target Database | T00864 |
ChEMBL | CHEMBL3785 |
IUPHAR | 312 |
DrugBank | BE0000635 |
Name | CHEMBL394441 |
---|---|
Molecular formula | C11H9ClN2O2 |
IUPAC name | 5-[(3-chlorophenyl)methyl]-1H-pyrazole-3-carboxylic acid |
Molecular weight | 236.655 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 2 |
XlogP | 2.7 |
Synonyms | AKOS030620128 5-(3-Chloro-benzyl)-1H-pyrazole-3-carboxylic acid DTXSID30472377 1H-Pyrazole-3-carboxylic acid, 5-[(3-chlorophenyl)methyl]- BDBM50216550 [ Show all ] |
Inchi Key | UYMDSFKYOCEPFN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C11H9ClN2O2/c12-8-3-1-2-7(4-8)5-9-6-10(11(15)16)14-13-9/h1-4,6H,5H2,(H,13,14)(H,15,16) |
PubChem CID | 11776293 |
ChEMBL | CHEMBL394441 |
IUPHAR | N/A |
BindingDB | 50216550 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 6200.0 nM | PMID17588745 | BindingDB,ChEMBL |
IC50 | 4200.0 nM | PMID17452318 | BindingDB,ChEMBL |
Inhibition | 65.0 % | PMID17452318 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218