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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M2
Species	Homo sapiens (Human)
Gene	CHRM2
Synonym	cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 cholinergic receptor, muscarinic 2, cardiac cholinergic receptor, muscarinic 2 [ Show all ]
Disease	Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer Stabilize muscle contractions Unspecified Cardiovascular disorder Asthma Alzheimer disease [ Show all ]
Length	466
Amino acid sequence	MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProt	P08172
Protein Data Bank	5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8
GPCR-HGmod model	P08172
3D structure model	This structure is from PDB ID 5zkc.
BioLiP	BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338
Therapeutic Target Database	T46185
ChEMBL	CHEMBL211
IUPHAR	14
DrugBank	BE0000560

Ligand

Name	Oxotremorine M
Molecular formula	C11H19IN2O
IUPAC name	trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium;iodide
Molecular weight	322.19
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	None
Synonyms	HMS3262P10 N,N,N,-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide oxotremorine M iodide Tox21_500954 CCG-222258 CTK8G2226 HMS501C21 NCGC00094256-01 Oxotremorine-M iodide 63939-65-1 FCH2296542 MLS000859927 O-100 SR-01000075338-1 AOB4621 HMS3267E18 N,N,N-Trimethyl-4-(2-oxo-1-pyrolidinyl)-2-butyn-1-ammonium iodide Oxotremorine M, solid trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium iodide 2-Butyn-1-aminium, 4-(2-oxo-1-pyrrolidinyl)-N,N,N-trimethyl-, iodide ER95520000 LP00954 NCGC00261639-01 SMR000326788 AC1MHKBB HMS2233F17 MolPort-003-983-655 SR-01000075338-3 BN0401 CHEMBL23957 HMS3372B22 N,N,N-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide oxotremorine methiodide 4-(2-Oxo-1-pyrrolidinyl)-N,N,N-trimethyl-2-butyn-1-aminium iodide EU-0100954 LS-47470 NIOSH/ER9552000 SR-01000075338 AKOS024456364 [ Show all ]
Inchi Key	VVLMSCJCXMBGDI-UHFFFAOYSA-M
Inchi ID	InChI=1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1
PubChem CID	3027782
ChEMBL	CHEMBL23957
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Ki	107.15 nM	PMID18182302	ChEMBL

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