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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Homo sapiens (Human)
Gene	CHRM5
Synonym	M5R M5 receptor cholinergic receptor cholinergic receptor, muscarinic 5
Disease	Urinary incontinence Colitis Dysmenorrhea Irritable bowel syndrome Myasthenia gravis Neurological disease Schizophrenia Stomach ulcer Cognitive disorders Chronic obstructive pulmonary disease Allergic rhinitis Central and peripheral nervous diseases Brain diseases Amnesia [ Show all ]
Length	532
Amino acid sequence	MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08912
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79961
ChEMBL	CHEMBL2035
IUPHAR	17
DrugBank	BE0000247, BE0004890

Ligand

Name	Oxotremorine M
Molecular formula	C11H19IN2O
IUPAC name	trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium;iodide
Molecular weight	322.19
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	None
Synonyms	HMS3267E18 N,N,N-Trimethyl-4-(2-oxo-1-pyrolidinyl)-2-butyn-1-ammonium iodide Oxotremorine M, solid trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium iodide 2-Butyn-1-aminium, 4-(2-oxo-1-pyrrolidinyl)-N,N,N-trimethyl-, iodide ER95520000 LP00954 NCGC00261639-01 SMR000326788 AC1MHKBB BN0401 HMS2233F17 MolPort-003-983-655 SR-01000075338-3 CHEMBL23957 HMS3372B22 N,N,N-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide oxotremorine methiodide 4-(2-Oxo-1-pyrrolidinyl)-N,N,N-trimethyl-2-butyn-1-aminium iodide EU-0100954 LS-47470 NIOSH/ER9552000 SR-01000075338 AKOS024456364 CCG-222258 HMS3262P10 N,N,N,-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide oxotremorine M iodide Tox21_500954 CTK8G2226 HMS501C21 NCGC00094256-01 Oxotremorine-M iodide 63939-65-1 FCH2296542 MLS000859927 O-100 SR-01000075338-1 AOB4621 [ Show all ]
Inchi Key	VVLMSCJCXMBGDI-UHFFFAOYSA-M
Inchi ID	InChI=1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1
PubChem CID	3027782
ChEMBL	CHEMBL23957
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Activity	9.6 /s	PMID20716489	ChEMBL
EC50	2300.0 nM	PMID20716489	ChEMBL
TIME	2.889e-05 hr	PMID20716489	ChEMBL

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