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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanocortin receptor 4
Species	Mus musculus (Mouse)
Gene	Mc4r
Synonym	MC4 receptor MC4-R
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY
UniProt	P56450
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3719
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL214332
Molecular formula	C77H109N21O19S
IUPAC name	(4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-6-amino-1-[(2S)-2-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Molecular weight	1664.91
Hydrogen bond acceptor	23
Hydrogen bond donor	23
XlogP	-4.3
Synonyms	Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 2-Tyr-alpha-msh Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2 Msh, 2-tyrosine-alpha- Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 (2-D-Tyrosine)-alpha-msh 2-Tyrosine-alpha-msh Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH) 75487-36-4 alpha-Melanotropin, 2-D-tyrosine- Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 BDBM50029747 (alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 3,5-Ditritiotyr(2)-alpha-msh Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH) Msh, 2-tyr-alpha- Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2 alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2) [ Show all ]
Inchi Key	WHNFPRLDDSXQCL-UAZQEYIDSA-N
Inchi ID	InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1
PubChem CID	16132144
ChEMBL	CHEMBL214332
IUPHAR	N/A
BindingDB	50029747
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1.59 nM	PMID15857138	BindingDB,ChEMBL
EC50	1.7 nM	PMID26005535	BindingDB,ChEMBL
EC50	1.89 nM	PMID15615519	BindingDB,ChEMBL
EC50	1.93 nM	PMID15828845	BindingDB,ChEMBL
EC50	2.56 nM	PMID18271518	BindingDB,ChEMBL
EC50	2.9 nM	PMID26433448	BindingDB,ChEMBL
EC50	3.07 nM	PMID11405661	BindingDB,ChEMBL
EC50	4.0 nM	PMID26959173	ChEMBL
EC50	4.0 nM	PMID26959173	BindingDB
EC50	5.37 nM	PMID12477357, PMID15084118, PMID12086493, PMID12061882	BindingDB,ChEMBL
EC50	5.4 nM	PMID14643357	BindingDB,ChEMBL
EC50	8.8 nM	PMID14552781	BindingDB
EC50	8.8 nM	PMID14552781	ChEMBL
EC50	19.3 nM	PMID19635667	BindingDB,ChEMBL
EC50	2470.0 nM	PMID12781199	BindingDB,ChEMBL

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