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GPCR

NameNeuropeptide Y receptor type 4
SpeciesHomo sapiens (Human)
GeneNPY4R
SynonymNPY4-R
neuropeptide Y receptor type 4
pancreatic polypeptide receptor 1
PP1
Y4 receptor
DiseaseObesity
Diabetes
Schizophrenia
Length375
Amino acid sequenceMNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRRLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI
UniProtP50391
Protein Data BankN/A
GPCR-HGmod modelP50391
3D structure modelThis predicted structure model is from GPCR-EXP P50391.
BioLiPN/A
Therapeutic Target DatabaseT27944
ChEMBLCHEMBL4877
IUPHAR307
DrugBankBE0002418

Ligand

NameCHEMBL123410
Molecular formulaC22H24Cl2N2O
IUPAC name2-[(2,4-dichlorophenoxy)methyl]-1-methyl-3-(piperidin-1-ylmethyl)indole
Molecular weight403.347
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP5.4
SynonymsBDBM50060731
1-Methyl-2-[(2,4-dichlorophenoxy)methyl]-3-(piperidinomethyl)-1H-indole
2-(2,4-Dichloro-phenoxymethyl)-1-methyl-3-piperidin-1-ylmethyl-1H-indole
Inchi KeyCBTXBKZASCULII-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H24Cl2N2O/c1-25-20-8-4-3-7-17(20)18(14-26-11-5-2-6-12-26)21(25)15-27-22-10-9-16(23)13-19(22)24/h3-4,7-10,13H,2,5-6,11-12,14-15H2,1H3
PubChem CID10692519
ChEMBLCHEMBL123410
IUPHARN/A
BindingDB50060731
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID9371234BindingDB,ChEMBL

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