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GLASS

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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Homo sapiens (Human)
Gene	CHRM5
Synonym	M5R M5 receptor cholinergic receptor cholinergic receptor, muscarinic 5
Disease	Urinary incontinence Colitis Dysmenorrhea Irritable bowel syndrome Myasthenia gravis Neurological disease Schizophrenia Stomach ulcer Cognitive disorders Chronic obstructive pulmonary disease Allergic rhinitis Central and peripheral nervous diseases Brain diseases Amnesia [ Show all ]
Length	532
Amino acid sequence	MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08912
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79961
ChEMBL	CHEMBL2035
IUPHAR	17
DrugBank	BE0000247, BE0004890

Ligand

Name	procyclidine
Molecular formula	C19H29NO
IUPAC name	1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol
Molecular weight	287.447
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.1
Synonyms	BPBio1_000911 EINECS 201-023-0 KBio2_006478 LS-138139 Osnervan Procyclid Prosyklidin 1-Pyrrolidinepropanol, .alpha.-cyclohexyl-.alpha.-phenyl- Spectrum4_000489 AB00053533_15 WLN: T5NTJ A2XQR&- AL6TJ BRN 0088563 D0R1WR HSDB 7678 KBioSS_001342 NCGC00018186-04 Prestwick2_000844 Procyclidine (INN) 1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol Spamol 5-20-01-00250 (Beilstein Handbook Reference) Triciclidina AC1Q76Z5 C07378 DivK1c_000429 KBio2_001342 L001290 NSC-169103 Prociclidina [INN-Spanish] Procyclidinum [INN-Latin] 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol Spectrum2_001298 77-37-2 Tricyclamol Arpicolin BRD-A31800922-003-05-3 CHEMBL86715 Elorine KBio3_001733 Metanin Prestwick0_000844 Procyclidin .alpha.-Cyclohexyl-.alpha.-phenyl-1-pyrrolidinepropanol SBI-0051493.P003 1-PYRROLIDINEPROPANOL, alpha-CYCLOHEXYL-alpha-PHENYL- Spectrum5_001224 AB00053533_16 WYDUSKDSKCASEF-UHFFFAOYSA-N BSPBio_000827 IDI1_000429 Kemadrin NINDS_000429 Prestwick3_000844 Procyclidine [INN:BAN] 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol SPBio_001335 Triciloid AC1Q77DP CHEBI:8448 DTXSID2023515 KBio2_003910 Lergine NSC169103 Procidlidina Procyklidin 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol Spectrum3_000557 AB00053533 Vagosin BDBM50062598 BRD-A31800922-003-15-2 D08425 GTPL7280 KBioGR_000977 NCGC00018186-02 Prestwick1_000844 1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol SCHEMBL147344 107661-03-0 Spectrum_000862 AC1L1J8M BSPBio_002233 DB00387 KBio1_000429 Kemadrine NSC 169103 Prociclidina Procyclidinum 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol hydrochloride SPBio_002748 56172-67-9 Tricoloid API0008986 [ Show all ]
Inchi Key	WYDUSKDSKCASEF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
PubChem CID	4919
ChEMBL	CHEMBL86715
IUPHAR	N/A
BindingDB	50062598
DrugBank	DB00387
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	24.0 nM	PMID1346637	PDSP,BindingDB

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