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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesRattus norvegicus (Rat)
GeneHtr7
SynonymGPRFO
5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
5-HTx
5-HT7 receptor
5-HT7
[ Show all ]
DiseaseN/A for non-human GPCRs
Length448
Amino acid sequenceMMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProtP32305
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3223
IUPHAR12
DrugBankN/A

Ligand

NameSCHEMBL2273377
Molecular formulaC16H14F3NO
IUPAC name3-[3-[2-(trifluoromethyl)phenyl]phenoxy]azetidine
Molecular weight293.289
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.8
SynonymsCHEMBL3640569
BDBM105011
US8575364, 20
Inchi KeyCDWBIRXEOIVBEI-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H14F3NO/c17-16(18,19)15-7-2-1-6-14(15)11-4-3-5-12(8-11)21-13-9-20-10-13/h1-8,13,20H,9-10H2
PubChem CID46204422
ChEMBLCHEMBL3640569
IUPHARN/A
BindingDB105011
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki25.5 nM, NoneBindingDB,ChEMBL
Ki25.5 nMN/ABindingDB

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