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GPCR

NameProstaglandin E2 receptor EP4 subtype
SpeciesRattus norvegicus (Rat)
GenePtger4
SynonymEP2
EP4 receptor
PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
Prostanoid EP4 receptor
DiseaseN/A for non-human GPCRs
Length488
Amino acid sequenceMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProtP43114
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4086
IUPHAR343
DrugBankN/A

Ligand

NameCHEMBL1929527
Molecular formulaC22H31NO5S
IUPAC name4-[2-[(2R)-2-[(E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]butanoic acid
Molecular weight421.552
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP1.6
SynonymsSCHEMBL11929380
BDBM50360160
(13E,15S)-9-Oxo-15-hydroxy-16-[3-(methoxymethyl)phenyl]-5-thia-8-aza-17,18,19,20-tetranorprosta-13-ene-1-oic acid
Inchi KeyCERPXAWHPJKQQI-QOEWUMFVSA-N
Inchi IDInChI=1S/C22H31NO5S/c1-28-16-18-5-2-4-17(14-18)15-20(24)9-7-19-8-10-21(25)23(19)11-13-29-12-3-6-22(26)27/h2,4-5,7,9,14,19-20,24H,3,6,8,10-13,15-16H2,1H3,(H,26,27)/b9-7+/t19-,20+/m0/s1
PubChem CID56834112
ChEMBLCHEMBL1929527
IUPHARN/A
BindingDB50360160
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501.3 nMPMID22204740BindingDB,ChEMBL

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