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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	CHEMBL1081318
Molecular formula	C16H20N6
IUPAC name	1-cyano-3-[2-(1H-imidazol-5-yl)ethyl]-2-(3-phenylpropyl)guanidine
Molecular weight	296.378
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	2.0
Synonyms	BDBM50415651
Inchi Key	CGWIQIDEPCKACR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H20N6/c17-12-21-16(20-10-8-15-11-18-13-22-15)19-9-4-7-14-5-2-1-3-6-14/h1-3,5-6,11,13H,4,7-10H2,(H,18,22)(H2,19,20,21)
PubChem CID	44481485
ChEMBL	CHEMBL1081318
IUPHAR	N/A
BindingDB	50415651
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
pKb	>5.0 -	PMID19791743	ChEMBL

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