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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Homo sapiens (Human)
Gene	CHRM1
Synonym	cholinergic receptor cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS Chrm-1 M1 receptor M1R M1 muscarinic acetylcholine receptor [ Show all ]
Disease	Functional bowel syndrome; Irritable bowel syndrome Glaucoma Peptic ulcer Parkinsonism; Extrapyramidal disorders secondary to neuroleptic drug therapy Visceral spasms Parkinson's disease; Dystonia Parkinson's disease Neurological disease Neuropathic pain Overactive bladder disorder Excessive sweating; Stomach ulcer Cognitive disorders Chronic obstructive pulmonary disease Schizophrenia Schizophrenia; Dementia Schizophrenia; Schizoaffective disorders Unspecified Urinary incontinence Anesthesia Alzheimer disease Abdominal stomach pain; Irritable bowel syndrome [ Show all ]
Length	460
Amino acid sequence	MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P11229
Protein Data Bank	5cxv
GPCR-HGmod model	P11229
3D structure model	This structure is from PDB ID 5cxv.
BioLiP	BL0339262, BL0339261, BL0339263
Therapeutic Target Database	T28893
ChEMBL	CHEMBL216
IUPHAR	13
DrugBank	BE0000092

Ligand

Name	biperiden
Molecular formula	C21H29NO
IUPAC name	1-(2-bicyclo[2.2.1]hept-5-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol
Molecular weight	311.469
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.3
Synonyms	Biperidenum [INN-Latin] CS-1797 HMS2093N17 NCGC00182965-03 1-Bicycloheptenyl-1-phenyl-3-piperidino-propanol-1 Prestwick0_000502 1235-82-1 (hydrochloride) SR-05000001649-1 514-65-8 alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidino propanol Bicyclo[2.2.1]hept-5-ene-2-methanol, .alpha.-phenyl-.alpha.-[2-(1-piperidinyl)ethyl]- Biperiden [USAN:INN:BAN:JAN] Biperidene hydrochloride BRN 0290038 KL 373 0FRP6G56LD NSC-759145 1-Piperidinepropanol, .alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl- SBI-0206797.P001 3-Piperidino-1-phenyl-1-bicycloheptenyl-1-propanol YSXKPIUOCJLQIE-UHFFFAOYSA-N Akineton alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol Biperiden (JAN/USP/INN) Biperideno [INN-Spanish] CHEBI:3112 EINECS 208-184-6 NCGC00182965-01 1-(Bicyclo(2.2.1)hept-5-en-2alpha-yl)-1-phenyl-3-piperidinopropanol PDSP2_000808 1-Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl- SPBio_002344 5-Norbornene-2-methanol, alpha-phenyl-alpha-(2-piperidinoethyl)- Akinophyl (Salt/Mix) BDBM50240680 Biperiden lactate Biperidine D00779 HSDB 7639 .alpha.-(Bicyclo(2.2.1)hept-5-en-2-yl)-.alpha.-phenyl-1-piperidino propanol NCGC00182965-04 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-(1-piperidinyl)-1-propanol # Prestwick1_000502 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) UNII-0FRP6G56LD alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol Bipariden Biperiden [USP:INN:BAN:JAN] Biperidene [INN-French] C07941 DB00810 L001222 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol NSC759145 1-Piperidinepropanol, .alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl-, hydrochloride SCHEMBL20229360 5-20-02-00242 (Beilstein Handbook Reference) Akineton (TN) AN-45471 Biperiden HCl Biperidenum CHEMBL1101 GTPL7128 NCGC00182965-02 1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol Pharmakon1600-01505514 1-{bicyclo[2.2.1]hept-5-en-2-yl}-1-phenyl-3-(piperidin-1-yl)propan-1-ol SR-05000001649 AKOS016008819 Beperiden Biperiden [USAN:BAN:INN:JAN] Biperidene BRD-A00546892-001-01-8 D0B4TN HY-13204A .alpha.-5-Norbornen-2-yl-.alpha.-phenyl-1-piperidinepropanol NCIOpen2_009564 1-Piperidinepropanol, .alpha.-5-norbornen-2-yl-.alpha.-phenyl- Prestwick2_000502 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) [German] VA10409 AC1L1DJT alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol Biperideno CCG-213474 DTXSID6022680 LS-116068 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol PDSP1_000821 1-PIPERIDINEPROPANOL, alpha-5-NORBORNEN-2-YL-alpha-PHENYL- SCHEMBL34957 5-Norbornene-2-methanol, .alpha.-phenyl-.alpha.-(2-piperidinoethyl)- Akinophyl AX8116739 Biperiden hydrochloride [ Show all ]
Inchi Key	YSXKPIUOCJLQIE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2
PubChem CID	2381
ChEMBL	N/A
IUPHAR	7128
BindingDB	50240680
DrugBank	DB00810
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Kd	0.48 nM	PMID1346637	IUPHAR
Ki	0.48 nM	PMID1346637	PDSP,BindingDB

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