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Name | Histamine H1 receptor |
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Species | Cavia porcellus (Guinea pig) |
Gene | HRH1 |
Synonym | H1R HH1R |
Disease | N/A for non-human GPCRs |
Length | 488 |
Amino acid sequence | MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP |
UniProt | P31389 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3943 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL87583 |
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Molecular formula | C15H16F3N3 |
IUPAC name | N-[2-[2-[3-(trifluoromethyl)phenyl]-1H-imidazol-5-yl]ethyl]cyclopropanamine |
Molecular weight | 295.309 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 3.0 |
Synonyms | BDBM50403678 |
Inchi Key | CIXJCCIPLDBDFN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C15H16F3N3/c16-15(17,18)11-3-1-2-10(8-11)14-20-9-13(21-14)6-7-19-12-4-5-12/h1-3,8-9,12,19H,4-7H2,(H,20,21) |
PubChem CID | 44320708 |
ChEMBL | CHEMBL87583 |
IUPHAR | N/A |
BindingDB | 50403678 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Emax | 20.0 % | PMID9873585 | ChEMBL |
Emax | 36.0 % | PMID9873585 | ChEMBL |
Kd | 0.741 nM | PMID9873585 | BindingDB |
Kd | 0.7413 nM | PMID9873585 | ChEMBL |
pKp | 6.12 - | PMID9873585 | ChEMBL |
Relative potency | 28.0 % | PMID9873585 | ChEMBL |
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