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Name | Nociceptin receptor |
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Species | Homo sapiens (Human) |
Gene | OPRL1 |
Synonym | Orphanin FQ receptor OP4 NOPr NOP-r NOP receptor [ Show all ] |
Disease | Inflammatory disease Major depressive disorder Central nervous system disease Heart failure Anxiety disorder [ Show all ] |
Length | 370 |
Amino acid sequence | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA |
UniProt | P41146 |
Protein Data Bank | 5dhh, 5dhg, 4ea3 |
GPCR-HGmod model | P41146 |
3D structure model | This structure is from PDB ID 5dhh. |
BioLiP | BL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294 |
Therapeutic Target Database | T52921 |
ChEMBL | CHEMBL2014 |
IUPHAR | 320 |
DrugBank | BE0002378 |
Name | CHEMBL111233 |
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Molecular formula | C23H21ClF3NO |
IUPAC name | 4-[4-chloro-3-(trifluoromethyl)phenyl]-1-(naphthalen-2-ylmethyl)piperidin-4-ol |
Molecular weight | 419.872 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 5.7 |
Synonyms | 4-(4-Chloro-3-trifluoromethyl-phenyl)-1-naphthalen-2-ylmethyl-piperidin-4-ol BDBM50132662 |
Inchi Key | ZNWWFIQDEPGZND-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H21ClF3NO/c24-21-8-7-19(14-20(21)23(25,26)27)22(29)9-11-28(12-10-22)15-16-5-6-17-3-1-2-4-18(17)13-16/h1-8,13-14,29H,9-12,15H2 |
PubChem CID | 44339463 |
ChEMBL | CHEMBL111233 |
IUPHAR | N/A |
BindingDB | 50132662 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Inhibition | 70.0 % | PMID12951102 | ChEMBL |
Ki | 879.0 nM | PMID12951102, PMID15454210 | BindingDB,ChEMBL |
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