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GPCR

NameCannabinoid receptor 2
SpeciesHomo sapiens (Human)
GeneCNR2
SynonymPeripheral cannabinoid receptor
rCB2
hCB2
cannabinoid receptor 2 (macrophage)
cannabinoid receptor 2 (spleen)
[ Show all ]
DiseaseImmune disorder
Inflammatory bowel disease
Inflammatory disease
Neuropathic pain
Osteoporosis
[ Show all ]
Length360
Amino acid sequenceMEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProtP34972
Protein Data Bank5zty
GPCR-HGmod modelP34972
3D structure modelThis structure is from PDB ID 5zty.
BioLiPBL0438927
Therapeutic Target DatabaseT37693
ChEMBLCHEMBL253
IUPHAR57
DrugBankBE0000095

Ligand

NameCHEMBL576709
Molecular formulaC15H14F2N2O
IUPAC name4-[5-(2,3-difluorophenyl)pyridin-2-yl]morpholine
Molecular weight276.287
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP2.8
SynonymsBDBM50415120
Inchi KeyAFOUIDYNAJCSAP-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H14F2N2O/c16-13-3-1-2-12(15(13)17)11-4-5-14(18-10-11)19-6-8-20-9-7-19/h1-5,10H,6-9H2
PubChem CID45486216
ChEMBLCHEMBL576709
IUPHARN/A
BindingDB50415120
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50251.19 nMPMID19864133BindingDB,ChEMBL
Efficacy58.0 %PMID19864133ChEMBL

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