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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Proteinase-activated receptor 4
Species	Homo sapiens (Human)
Gene	F2RL3
Synonym	protease-activated receptor 4 PAR4 PAR-4 F2R like thrombin/trypsin receptor 3 coagulation factor II receptor-like 3 coagulation factor II (thrombin) receptor-like 3 Thrombin receptor-like 3 [ Show all ]
Disease	N/A
Length	385
Amino acid sequence	MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProt	Q96RI0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RI0
3D structure model	This predicted structure model is from GPCR-EXP Q96RI0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4691
IUPHAR	350
DrugBank	N/A

Ligand

Name	CHEMBL3334899
Molecular formula	C24H21F3N2O4S
IUPAC name	[3-(6-methoxypyridin-3-yl)-5-methylsulfonyl-1-[[3-(trifluoromethyl)phenyl]methyl]indol-2-yl]methanol
Molecular weight	490.497
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	3.7
Synonyms	SCHEMBL17616310
Inchi Key	BVIFZQSTLISWHW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H21F3N2O4S/c1-33-22-9-6-16(12-28-22)23-19-11-18(34(2,31)32)7-8-20(19)29(21(23)14-30)13-15-4-3-5-17(10-15)24(25,26)27/h3-12,30H,13-14H2,1-2H3
PubChem CID	118714111
ChEMBL	CHEMBL3334899
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
%max	89.0 %	PMID25176330	ChEMBL

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