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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3354790
Molecular formula	C24H18F3N3O3
IUPAC name	methyl 3-benzyl-10-[4-(trifluoromethyl)phenyl]-4-oxa-1,8,12-triazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraene-3-carboxylate
Molecular weight	453.421
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	4.0
Synonyms	BDBM50036659
Inchi Key	CXMRNHROHROMRX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H18F3N3O3/c1-32-22(31)23(11-15-5-3-2-4-6-15)20-17(14-33-23)12-28-21-19(13-29-30(20)21)16-7-9-18(10-8-16)24(25,26)27/h2-10,12-13H,11,14H2,1H3
PubChem CID	118720418
ChEMBL	CHEMBL3354790
IUPHAR	N/A
BindingDB	50036659
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	34.0 nM	PMID25455488	BindingDB,ChEMBL
Efficacy	77.0 %	PMID25455488	ChEMBL

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