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GPCR

NameFree fatty acid receptor 4
SpeciesHomo sapiens (Human)
GeneFFAR4
SynonymO3FAR1
G-protein coupled receptor 120
GPR120
G-protein-coupled receptor GT01
G-protein coupled receptor PGR4
[ Show all ]
DiseaseN/A
Length377
Amino acid sequenceMSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProtQ5NUL3
Protein Data BankN/A
GPCR-HGmod modelQ5NUL3
3D structure modelThis predicted structure model is from GPCR-EXP Q5NUL3.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5339
IUPHAR127
DrugBankBE0003399

Ligand

NameCHEMBL3311320
Molecular formulaC19H25NO2S
IUPAC name4-tert-butyl-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Molecular weight331.474
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.2
Synonyms4-tert-butyl-N-mesitylbenzenesulfonamide
AC1LHBKK
Oprea1_519894
Oprea1_834286
MolPort-002-347-623
[ Show all ]
Inchi KeyFFIUKRRUBSQJBQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H25NO2S/c1-13-11-14(2)18(15(3)12-13)20-23(21,22)17-9-7-16(8-10-17)19(4,5)6/h7-12,20H,1-6H3
PubChem CID835355
ChEMBLCHEMBL3311320
IUPHARN/A
BindingDB50044916
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC50<31622.8 nMPMID24881566ChEMBL
EC50>31623.0 nMPMID24881566BindingDB

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