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Name | Metabotropic glutamate receptor 2 |
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Species | Homo sapiens (Human) |
Gene | GRM2 |
Synonym | mGluR2 mGlu2 receptor metabotropic glutamate receptor 2 GPRC1B glutamate receptor |
Disease | Central nervous system disease Anxiety disorder Bipolar disorder Major depressive disorder Mood disorder [ Show all ] |
Length | 872 |
Amino acid sequence | MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL |
UniProt | Q14416 |
Protein Data Bank | 5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 5cnj. |
BioLiP | BL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443 |
Therapeutic Target Database | T62820 |
ChEMBL | CHEMBL5137 |
IUPHAR | 290 |
DrugBank | N/A |
Name | CHEMBL1629864 |
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Molecular formula | C21H15Cl2N3O |
IUPAC name | 7,8-dichloro-4-[3-(2-methylpyridin-4-yl)phenyl]-1,3-dihydro-1,5-benzodiazepin-2-one |
Molecular weight | 396.271 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 4.6 |
Synonyms | 7,8-dichloro-4-[3-(2-methyl-pyridin-4-yl)-phenyl]-1,3-dihydro-benzo[b][1,4]diazepin-2-one BDBM50332966 CMLVJJVYIVBZNH-UHFFFAOYSA-N 7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H-benzo[b][1,4]diazepin-2(3H)-one SCHEMBL5557296 |
Inchi Key | CMLVJJVYIVBZNH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H15Cl2N3O/c1-12-7-14(5-6-24-12)13-3-2-4-15(8-13)18-11-21(27)26-20-10-17(23)16(22)9-19(20)25-18/h2-10H,11H2,1H3,(H,26,27) |
PubChem CID | 11304010 |
ChEMBL | CHEMBL1629864 |
IUPHAR | N/A |
BindingDB | 50332966 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 2.0 nM | PMID20971004 | BindingDB |
IC50 | 4.0 nM | PMID20971004 | BindingDB |
IC50 | 7.0 nM | PMID20971004 | BindingDB,ChEMBL |
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