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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1771098
Molecular formula	C24H28ClFN4O2
IUPAC name	4-[2-[2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl]ethoxy]-N-cyclopropyl-2-fluorobenzamide
Molecular weight	458.962
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.8
Synonyms	(-)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethoxy)-N-cyclopropyl-2-fluorobenzamide BDBM50342697 SCHEMBL1186458 (rac)-cis-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethoxy)-N-cyclopropyl-2-fluorobenzamide (+)-trans-4-(2-(2-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)cyclopropyl)ethoxy)-N-cyclopropyl-2-fluorobenzamide
Inchi Key	CMRYHKUOCWIKMH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H28ClFN4O2/c25-17-13-27-24(28-14-17)30-8-5-15(6-9-30)21-11-16(21)7-10-32-19-3-4-20(22(26)12-19)23(31)29-18-1-2-18/h3-4,12-16,18,21H,1-2,5-11H2,(H,29,31)
PubChem CID	54587813
ChEMBL	CHEMBL1771098
IUPHAR	N/A
BindingDB	50342697
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.3 nM	PMID21273063	BindingDB,ChEMBL
EC50	3.0 nM	PMID21273063	BindingDB,ChEMBL
EC50	14.0 nM	PMID21273063	BindingDB,ChEMBL

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