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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Endothelin-1 receptor
Species	Rattus norvegicus (Rat)
Gene	Ednra
Synonym	endothelin A receptor Endothelin receptor type A {ECO:0000312\|RGD:2535} ENDOR endothelin-1 receptor ET-A ET-AR ETA receptor Gpcr10 [ Show all ]
Disease	N/A for non-human GPCRs
Length	426
Amino acid sequence	MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
UniProt	P26684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4566
IUPHAR	219
DrugBank	N/A

Ligand

Name	CHEMBL62450
Molecular formula	C31H24O7
IUPAC name	2-(1,3-benzodioxol-5-yl)-4-(4-methoxyphenyl)-6-phenylmethoxy-2H-chromene-3-carboxylic acid
Molecular weight	508.526
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	5.6
Synonyms	BDBM50112731 2-Benzo[1,3]dioxol-5-yl-6-benzyloxy-4-(4-methoxy-phenyl)-2H-chromene-3-carboxylic acid
Inchi Key	CNCGFZQOGNWAMP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H24O7/c1-34-22-10-7-20(8-11-22)28-24-16-23(35-17-19-5-3-2-4-6-19)12-14-25(24)38-30(29(28)31(32)33)21-9-13-26-27(15-21)37-18-36-26/h2-16,30H,17-18H2,1H3,(H,32,33)
PubChem CID	10918216
ChEMBL	CHEMBL62450
IUPHAR	N/A
BindingDB	50112731
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	62.0 nM	PMID11985472	BindingDB,ChEMBL

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