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Name | Glucagon receptor |
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Species | Homo sapiens (Human) |
Gene | GCGR |
Synonym | GL-R GGR GR glucagon receptor |
Disease | Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes [ Show all ] |
Length | 477 |
Amino acid sequence | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF |
UniProt | P47871 |
Protein Data Bank | 5yqz, 5xez, 5ee7, 5xf1 |
GPCR-HGmod model | P47871 |
3D structure model | This structure is from PDB ID 5yqz. |
BioLiP | BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437 |
Therapeutic Target Database | T60182, T87875 |
ChEMBL | CHEMBL1985 |
IUPHAR | 251 |
DrugBank | N/A |
Name | 643011-22-7 |
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Molecular formula | C27H21ClF3N3O3S |
IUPAC name | 3-[[4-[[N-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]-4-(trifluoromethyl)anilino]methyl]benzoyl]amino]propanoic acid |
Molecular weight | 559.988 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 2 |
XlogP | 6.4 |
Synonyms | b-Alanine,N-[4-[[[4-(4-chlorophenyl)-2-thiazolyl][4-(trifluoromethyl)phenyl]amino]methyl]benzoyl]- CHEMBL470729 ZINC3933425 BDBM29121 KB-81596 [ Show all ] |
Inchi Key | CTJDFSIKSQVUTF-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H21ClF3N3O3S/c28-21-9-5-18(6-10-21)23-16-38-26(33-23)34(22-11-7-20(8-12-22)27(29,30)31)15-17-1-3-19(4-2-17)25(37)32-14-13-24(35)36/h1-12,16H,13-15H2,(H,32,37)(H,35,36) |
PubChem CID | 9985258 |
ChEMBL | CHEMBL470729 |
IUPHAR | N/A |
BindingDB | 29121 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 92.0 nM | PMID19385613 | BindingDB,ChEMBL |
IC50 | 93.0 nM | PMID19385613 | ChEMBL |
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