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GPCR

NameUrotensin-2 receptor
SpeciesHomo sapiens (Human)
GeneUTS2R
SynonymSENR (sensory epithelial neuropeptide-like receptor)
UII-R1
UT receptor
UR-2-R
UTR2
[ Show all ]
DiseaseAsthma
Diabetic nephropathy
Renal failure
Length389
Amino acid sequenceMALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
UniProtQ9UKP6
Protein Data BankN/A
GPCR-HGmod modelQ9UKP6
3D structure modelThis predicted structure model is from GPCR-EXP Q9UKP6.
BioLiPN/A
Therapeutic Target DatabaseT49072
ChEMBLCHEMBL3764
IUPHAR365
DrugBankN/A

Ligand

NameCHEMBL410825
Molecular formulaC24H40N4O3
IUPAC name(2S)-2-acetamido-N-[(3S)-1-[[4-[3-(dimethylamino)propoxy]phenyl]methyl]pyrrolidin-3-yl]-4-methylpentanamide
Molecular weight432.609
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.7
SynonymsN/A
Inchi KeyCWVDSPSUXSWOOC-GMAHTHKFSA-N
Inchi IDInChI=1S/C24H40N4O3/c1-18(2)15-23(25-19(3)29)24(30)26-21-11-13-28(17-21)16-20-7-9-22(10-8-20)31-14-6-12-27(4)5/h7-10,18,21,23H,6,11-17H2,1-5H3,(H,25,29)(H,26,30)/t21-,23-/m0/s1
PubChem CID44399083
ChEMBLCHEMBL410825
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2511.89 nMPMID15936190ChEMBL

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