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Name | Type-1 angiotensin II receptor |
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Species | Homo sapiens (Human) |
Gene | AGTR1 |
Synonym | Type-1 angiotensin II receptor HAT1R Agtr-1a type-1A angiotensin II receptor AT1 [ Show all ] |
Disease | Metabolic syndrome x Myocardial infarction Hypertension Restenosis Alzheimer disease [ Show all ] |
Length | 359 |
Amino acid sequence | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE |
UniProt | P30556 |
Protein Data Bank | 6do1, 4zud, 4yay |
GPCR-HGmod model | P30556 |
3D structure model | This structure is from PDB ID 6do1. |
BioLiP | BL0312790, BL0326733, BL0439004,BL0439005 |
Therapeutic Target Database | T74456 |
ChEMBL | CHEMBL227 |
IUPHAR | 34 |
DrugBank | BE0000062 |
Name | CHEMBL70726 |
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Molecular formula | C40H40FN3O7S |
IUPAC name | (2-benzoylphenyl)methyl 5-ethyl-3-[[2-fluoro-4-[2-(propoxycarbonylsulfamoyl)phenyl]phenyl]methyl]-2-propylimidazole-4-carboxylate |
Molecular weight | 725.832 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 1 |
XlogP | 8.4 |
Synonyms | SCHEMBL244431 BDBM50283248 L012016 |
Inchi Key | CWWCXCYXJZGDSQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C40H40FN3O7S/c1-4-14-36-42-34(6-3)37(39(46)51-26-30-17-10-11-19-32(30)38(45)27-15-8-7-9-16-27)44(36)25-29-22-21-28(24-33(29)41)31-18-12-13-20-35(31)52(48,49)43-40(47)50-23-5-2/h7-13,15-22,24H,4-6,14,23,25-26H2,1-3H3,(H,43,47) |
PubChem CID | 19430442 |
ChEMBL | CHEMBL70726 |
IUPHAR | N/A |
BindingDB | 50283248 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.28 nM | N/A | BindingDB |
IC50 | 0.28 nM | Bioorg. Med. Chem. Lett., (1994) 4:18:2235 | ChEMBL |
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