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GPCR

NameUrotensin-2 receptor
SpeciesHomo sapiens (Human)
GeneUTS2R
SynonymSENR (sensory epithelial neuropeptide-like receptor)
UII-R1
UT receptor
UR-2-R
UTR2
[ Show all ]
DiseaseAsthma
Diabetic nephropathy
Renal failure
Length389
Amino acid sequenceMALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
UniProtQ9UKP6
Protein Data BankN/A
GPCR-HGmod modelQ9UKP6
3D structure modelThis predicted structure model is from GPCR-EXP Q9UKP6.
BioLiPN/A
Therapeutic Target DatabaseT49072
ChEMBLCHEMBL3764
IUPHAR365
DrugBankN/A

Ligand

NameCHEMBL204516
Molecular formulaC21H23ClN2O2
IUPAC name[1-(4-chlorophenyl)-3-(dimethylamino)propyl] 1-methylindole-3-carboxylate
Molecular weight370.877
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP4.4
SynonymsN/A
Inchi KeyCXDNKHGNUKSCRG-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H23ClN2O2/c1-23(2)13-12-20(15-8-10-16(22)11-9-15)26-21(25)18-14-24(3)19-7-5-4-6-17(18)19/h4-11,14,20H,12-13H2,1-3H3
PubChem CID44409534
ChEMBLCHEMBL204516
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501513.56 nMPMID16570919ChEMBL
Efficacy104.0 %PMID16570919ChEMBL

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