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Name | Histamine H4 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH4 |
Synonym | Pfi-013 SP9144 HH4R H4R H4 receptor [ Show all ] |
Disease | Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis |
Length | 390 |
Amino acid sequence | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS |
UniProt | Q9H3N8 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9H3N8 |
3D structure model | This predicted structure model is from GPCR-EXP Q9H3N8. |
BioLiP | N/A |
Therapeutic Target Database | T26500 |
ChEMBL | CHEMBL3759 |
IUPHAR | 265 |
DrugBank | BE0000146 |
Name | CHEMBL3805220 |
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Molecular formula | C19H24N6S |
IUPAC name | 1-cyano-2-[[(1R,3R)-3-(1H-imidazol-5-yl)cyclopentyl]methyl]-3-(2-phenylsulfanylethyl)guanidine |
Molecular weight | 368.503 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 3 |
XlogP | 2.8 |
Synonyms | BDBM50170155 |
Inchi Key | MMZLYDNVAYWZLR-HZPDHXFCSA-N |
Inchi ID | InChI=1S/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/m1/s1 |
PubChem CID | 127049855 |
ChEMBL | CHEMBL3805220 |
IUPHAR | N/A |
BindingDB | 50170155 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 500.0 nM | PMID27007611 | BindingDB,ChEMBL |
Intrinsic activity | 0.0 - | PMID27007611 | ChEMBL |
Intrinsic activity | 0.6 - | PMID27007611 | ChEMBL |
Kb | 7700.0 nM | PMID27007611 | ChEMBL |
Ki | 1050.0 nM | PMID27007611 | BindingDB,ChEMBL |
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