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GLASS

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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	SCHEMBL2586921
Molecular formula	C22H23N3O2
IUPAC name	(4S,5S)-5-butyl-4-methyl-3-(2-phenyl-1,3-benzoxazol-6-yl)-4,5-dihydro-1H-pyridazin-6-one
Molecular weight	361.445
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.0
Synonyms	US8772323, 197 CHEMBL3940831 BDBM180629
Inchi Key	ACAFIORPGNSDEH-YOEHRIQHSA-N
Inchi ID	InChI=1S/C22H23N3O2/c1-3-4-10-17-14(2)20(24-25-21(17)26)16-11-12-18-19(13-16)27-22(23-18)15-8-6-5-7-9-15/h5-9,11-14,17H,3-4,10H2,1-2H3,(H,25,26)/t14-,17-/m0/s1
PubChem CID	67464400
ChEMBL	CHEMBL3940831
IUPHAR	N/A
BindingDB	180629
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1114.0 nM	, None	BindingDB,ChEMBL

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