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GPCR

NameCannabinoid receptor 2
SpeciesHomo sapiens (Human)
GeneCNR2
SynonymPeripheral cannabinoid receptor
rCB2
hCB2
cannabinoid receptor 2 (macrophage)
cannabinoid receptor 2 (spleen)
[ Show all ]
DiseaseImmune disorder
Inflammatory bowel disease
Inflammatory disease
Neuropathic pain
Osteoporosis
[ Show all ]
Length360
Amino acid sequenceMEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProtP34972
Protein Data Bank5zty
GPCR-HGmod modelP34972
3D structure modelThis structure is from PDB ID 5zty.
BioLiPBL0438927
Therapeutic Target DatabaseT37693
ChEMBLCHEMBL253
IUPHAR57
DrugBankBE0000095

Ligand

NameCHEMBL3925964
Molecular formulaC29H27ClF3N3O5S
IUPAC name6-[(4-chlorophenyl)-hydroxy-(4-methoxyphenyl)methyl]-4-[[1-(trifluoromethylsulfonyl)piperidin-4-yl]amino]-1H-quinolin-2-one
Molecular weight622.056
Hydrogen bond acceptor10
Hydrogen bond donor3
XlogP5.0
SynonymsSCHEMBL17025470
Inchi KeyACYOKFLYYBAFPS-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H27ClF3N3O5S/c1-41-23-9-4-19(5-10-23)28(38,18-2-7-21(30)8-3-18)20-6-11-25-24(16-20)26(17-27(37)35-25)34-22-12-14-36(15-13-22)42(39,40)29(31,32)33/h2-11,16-17,22,38H,12-15H2,1H3,(H2,34,35,37)
PubChem CID118323982
ChEMBLCHEMBL3925964
IUPHARN/A
BindingDB208280
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC508280.0 nM, NoneBindingDB,ChEMBL

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