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GLASS

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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3926629
Molecular formula	C29H39N3O3
IUPAC name	tert-butyl 4-[cyclopropyl-[4-[4-[(dimethylamino)methyl]phenyl]benzoyl]amino]piperidine-1-carboxylate
Molecular weight	477.649
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.8
Synonyms	SCHEMBL15514805 US9469631, 112 BDBM254711
Inchi Key	AIVZPMPAOHEFMY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H39N3O3/c1-29(2,3)35-28(34)31-18-16-26(17-19-31)32(25-14-15-25)27(33)24-12-10-23(11-13-24)22-8-6-21(7-9-22)20-30(4)5/h6-13,25-26H,14-20H2,1-5H3
PubChem CID	90000794
ChEMBL	CHEMBL3926629
IUPHAR	N/A
BindingDB	254711
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1742.0 nM	, None	BindingDB,ChEMBL

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