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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL3961160
Molecular formulaC30H36F4N4O4
IUPAC name(6S,9R,12R)-6-cyclopropyl-12-[(4-fluorophenyl)methyl]-8,9-dimethyl-20-(trifluoromethyl)-2-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(18),19,21-triene-7,10,13-trione
Molecular weight592.636
Hydrogen bond acceptor9
Hydrogen bond donor3
XlogP4.2
SynonymsSCHEMBL16387072
Inchi KeyAWOSXADKXZMNNO-UFKXBGGNSA-N
Inchi IDInChI=1S/C30H36F4N4O4/c1-18-27(39)37-24(16-19-5-10-23(31)11-6-19)28(40)36-13-3-4-21-17-22(30(32,33)34)9-12-25(21)42-15-14-35-26(20-7-8-20)29(41)38(18)2/h5-6,9-12,17-18,20,24,26,35H,3-4,7-8,13-16H2,1-2H3,(H,36,40)(H,37,39)/t18-,24-,26+/m1/s1
PubChem CID117812381
ChEMBLCHEMBL3961160
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki100.0 nMNoneChEMBL

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