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GPCR

NameFree fatty acid receptor 4
SpeciesHomo sapiens (Human)
GeneFFAR4
SynonymO3FAR1
G-protein coupled receptor 120
GPR120
G-protein-coupled receptor GT01
G-protein coupled receptor PGR4
[ Show all ]
DiseaseN/A
Length377
Amino acid sequenceMSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProtQ5NUL3
Protein Data BankN/A
GPCR-HGmod modelQ5NUL3
3D structure modelThis predicted structure model is from GPCR-EXP Q5NUL3.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5339
IUPHAR127
DrugBankBE0003399

Ligand

NameCHEMBL3908362
Molecular formulaC18H13FN2O3S
IUPAC name2-(3-fluoro-5-pyridin-3-yloxyphenyl)-3H-1,2-benzothiazole 1,1-dioxide
Molecular weight356.371
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP2.8
SynonymsSCHEMBL1724515
BDBM50196325
Inchi KeyGTUWFJSMHUOHTQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H13FN2O3S/c19-14-8-15(10-17(9-14)24-16-5-3-7-20-11-16)21-12-13-4-1-2-6-18(13)25(21,22)23/h1-11H,12H2
PubChem CID46892131
ChEMBLCHEMBL3908362
IUPHARN/A
BindingDB50196325
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50181.97 nMPMID27570890ChEMBL
EC50182.0 nMPMID27570890BindingDB
EC50302.0 nMPMID27570890BindingDB,ChEMBL
EC50436.52 nMPMID27570890ChEMBL
EC50437.0 nMPMID27570890BindingDB
Emax107.0 %PMID27570890ChEMBL
Emax115.0 %PMID27570890ChEMBL

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