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Name | Muscarinic acetylcholine receptor M3 |
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Species | Homo sapiens (Human) |
Gene | CHRM3 |
Synonym | cholinergic receptor cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 HM4 [ Show all ] |
Disease | Urinary incontinence Overactive bladder Overactive bladder disorder Postoperative nausea and vomiting Respiratory disease [ Show all ] |
Length | 590 |
Amino acid sequence | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL |
UniProt | P20309 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T67684 |
ChEMBL | CHEMBL245 |
IUPHAR | 15 |
DrugBank | BE0000045 |
Name | 2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine |
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Molecular formula | C15H17N3 |
IUPAC name | 2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine |
Molecular weight | 239.322 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 2.1 |
Synonyms | PHA-670080 BDBM50342538 PNU-57378E CZWQBSKNHUVZLI-UHFFFAOYSA-N PF-3246799 [ Show all ] |
Inchi Key | CZWQBSKNHUVZLI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C15H17N3/c1-2-4-12(5-3-1)10-15-17-11-13-6-8-16-9-7-14(13)18-15/h1-5,11,16H,6-10H2 |
PubChem CID | 25070582 |
ChEMBL | CHEMBL1770373 |
IUPHAR | N/A |
BindingDB | 50342538 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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IC50 | 300.0 nM | PMID21195614 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218