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GPCR

NameFree fatty acid receptor 4
SpeciesHomo sapiens (Human)
GeneFFAR4
SynonymO3FAR1
G-protein coupled receptor 120
GPR120
G-protein-coupled receptor GT01
G-protein coupled receptor PGR4
[ Show all ]
DiseaseN/A
Length377
Amino acid sequenceMSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProtQ5NUL3
Protein Data BankN/A
GPCR-HGmod modelQ5NUL3
3D structure modelThis predicted structure model is from GPCR-EXP Q5NUL3.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5339
IUPHAR127
DrugBankBE0003399

Ligand

NameCHEMBL3896657
Molecular formulaC18H12F4O4
IUPAC name3-[5-[2-fluoro-5-(trifluoromethoxy)phenyl]-1-benzofuran-2-yl]propanoic acid
Molecular weight368.284
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP5.0
SynonymsBDBM50203653
Inchi KeyHTIVRXDQROURHF-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H12F4O4/c19-15-4-2-13(26-18(20,21)22)9-14(15)10-1-5-16-11(7-10)8-12(25-16)3-6-17(23)24/h1-2,4-5,7-9H,3,6H2,(H,23,24)
PubChem CID134134229
ChEMBLCHEMBL3896657
IUPHARN/A
BindingDB50203653
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity73.0 %PMID27815121ChEMBL
EC5016.0 nMPMID28105274BindingDB,ChEMBL
EC5063.0 nMPMID28105274, PMID27815121BindingDB,ChEMBL
IC501.4 nMPMID28105274BindingDB
IC5051.0 nMPMID28105274BindingDB

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