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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	GNRHR
Synonym	LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R LHRH receptor GnRHR GNRHR1 luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor GnRH1 receptor [ Show all ]
Disease	Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease Prostate hyperplasia Unspecified Female infertility Esophageal cancer Endometriosis Controlled ovarian stimulation Cancer Advanced prostate cancer Acute lymphoblastic leukemia Hormone deficiency [ Show all ]
Length	328
Amino acid sequence	MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30968
Protein Data Bank	N/A
GPCR-HGmod model	P30968
3D structure model	This predicted structure model is from GPCR-EXP P30968.
BioLiP	N/A
Therapeutic Target Database	T12475
ChEMBL	CHEMBL1855
IUPHAR	256
DrugBank	BE0000203

Ligand

Name	Lutrepatch
Molecular formula	C60H73N15O13
IUPAC name	N-[1-[[1-[[1-[[1-[[2-[[1-[[1-[2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight	1212.34
Hydrogen bond acceptor	14
Hydrogen bond donor	15
XlogP	0.5
Synonyms	GnRH (Smart Patch, female infertility), Vyteris/Ferring Luteinizing hormone releasing hormone salmon D0R9VC Gonadotropin-releasing hormone (Smart Patch, female infertility), Vyteris/Ferring PYR-HIS-TRP-SER-TYR-GLY-TRP-LEU-PRO-GLY-NH2 GnRH (Lutrepatch, female infertility), Ferring/Vyteris Iontophoretic anti-infertility peptide (Smart Patch), Vyteris/Ferring Anti-infertility peptide (iontophoretic/Smart Patch), Ferring/Vyteris GnRH I Luteinizing hormone releasing hormone salmon, >=97% (HPLC) GnRH (Lutrepatch, female fertility) GTPL1162 GnRH (Smart Patch, female infertility), Ferring/Vyteris LH-RH (LHRH) Anti-infertility peptide (iontophoretic/Smart Patch), Vyteris/Ferring Gonadotropin-releasing hormone (Smart Patch, female infertility), Ferring/Vyteris GnRH (Lutrepatch, female fertility), Ferring Iontophoretic anti-infertility peptide (Smart Patch), Ferring/Vyteris [ Show all ]
Inchi Key	NMJREATYWWNIKX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C60H73N15O13/c1-32(2)20-47(60(88)75-19-7-12-49(75)59(87)65-28-50(61)78)73-55(83)44(22-34-25-63-40-10-5-3-8-38(34)40)69-52(80)29-66-53(81)43(21-33-13-15-37(77)16-14-33)70-58(86)48(30-76)74-56(84)45(23-35-26-64-41-11-6-4-9-39(35)41)71-57(85)46(24-36-27-62-31-67-36)72-54(82)42-17-18-51(79)68-42/h3-6,8-11,13-16,25-27,31-32,42-49,63-64,76-77H,7,12,17-24,28-30H2,1-2H3,(H2,61,78)(H,62,67)(H,65,87)(H,66,81)(H,68,79)(H,69,80)(H,70,86)(H,71,85)(H,72,82)(H,73,83)(H,74,84)
PubChem CID	16132914
ChEMBL	N/A
IUPHAR	1162
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.1 nM	PMID26774084	IUPHAR
IC50	2.51188 nM	PMID17452338	IUPHAR
Kd	2.9 - 22.0 nM	PMID26398856	IUPHAR
Ki	3.98107 - 50.1187 nM	PMID11726197, PMID17095587	IUPHAR
Ki	4.0 - 13.0 nM	PMID26398856	IUPHAR

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