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GPCR

NameAlpha-1A adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra1a
Synonymalpha 1C-adrenergic receptor
Alpha-1C adrenergic receptor
ADRA1L1
Alpha-1A adrenoreceptor
alpha-1A adrenergic receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProtP43140
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL319
IUPHAR22
DrugBankN/A

Ligand

Name(1S,2R)-2-phenylcyclopropanamine
Molecular formulaC9H11N
IUPAC name(1S,2R)-2-phenylcyclopropan-1-amine
Molecular weight133.194
Hydrogen bond acceptor1
Hydrogen bond donor1
XlogP1.5
Synonyms3721-28-6
(1S,2R)-2-phenylcyclopropan-1-amine
(1S,2R)-2-Phenyl-cyclopropylamine
(1S,2R)-tranylcypromine
(+)-Tranylcypromine
[ Show all ]
Inchi KeyAELCINSCMGFISI-BDAKNGLRSA-N
Inchi IDInChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2/t8-,9+/m1/s1
PubChem CID26070
ChEMBLCHEMBL257990
IUPHARN/A
BindingDB50236898
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki940.0 nMPMID17827BindingDB
Ki7000.0 nMPMID17827BindingDB

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