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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameAlpha-1A adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra1a
Synonymalpha 1C-adrenergic receptor
Alpha-1C adrenergic receptor
ADRA1L1
Alpha-1A adrenoreceptor
alpha-1A adrenergic receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProtP43140
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL319
IUPHAR22
DrugBankN/A

Known ligands

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Total entries: 1075
Page:  / 11 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
902D structureEticloprideC17H25ClN2O3340.8484 / 23.1Yes
2612D structureCHEMBL122047C25H30ClFN4O2472.9894 / 04.5Yes
2762D structure2-{3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl}tetrahydro-1H-pyrrolo[1,2-c]imidazole-1,3(2H)-dioneC20H28N4O3372.4695 / 01.8Yes
11282D structureCHEMBL287965C24H24N4O3S448.5416 / 13.1Yes
20452D structureCHEMBL252818C24H28N4OS420.5755 / 14.1Yes
30402D structureCHEMBL1255085C23H25NO5395.4556 / 33.9Yes
5554862D structureStrychnine, Nb-oxideC21H22N2O3350.4183 / 01.4Yes
5554932D structure(1S,2R)-2-phenylcyclopropanamineC9H11N133.1941 / 11.5Yes
5554942D structuretranylcypromineC9H11N133.1941 / 11.5Yes
4418542D structureCHEMBL3342860C27H32F3N3O4519.5659 / 03.9No
45032D structureCHEMBL215151C24H26ClNO4427.9255 / 2N/AN/A
47312D structurelipoic acidC8H14O2S2206.3184 / 11.7Yes
57762D structureparoxetineC19H20FNO3329.3715 / 13.5Yes
69052D structureCHEMBL25098C33H37N3O4539.6766 / 15.6No
75812D structurep-CumaroylagmatinC14H20N4O2276.343 / 40.4Yes
75822D structurep-CoumaroylagmatineC14H20N4O2276.343 / 40.4Yes
4420222D structureCHEMBL3342852C19H28N2O3S364.5046 / 02.5Yes
78852D structureCHEMBL253878C30H32N4OS496.6735 / 15.7No
5361962D structureCHEMBL27021C19H24N2O296.4143 / 03.8Yes
87802D structureCHEMBL220515C24H26ClN5O2451.9555 / 13.6Yes
89002D structureEthanesulfonamide, N-[3-(3-pyrrolidinyl)phenyl]-C12H18N2O2S254.3484 / 21.0Yes
95472D structureGSK163090C25H29N5O415.5414 / 13.4Yes
99252D structureCHEMBL343188C18H18N8O5426.39311 / 11.1No
106252D structureCHEMBL145712C28H35FN4O462.6133 / 04.7Yes
107762D structureCHEMBL1242445C26H33N3O4451.5676 / 02.4Yes
107842D structureCHEMBL1242444C26H33N3O4451.5676 / 02.4Yes
4421322D structureCHEMBL3415012C24H30N4O2406.534 / 23.2Yes
111002D structureCHEMBL2261352C14H18N4O2274.3243 / 40.0Yes
112752D structureCHEMBL1946783C31H34N2O6530.6218 / 2N/ANo
115312D structure3-MPPIC23H25N5O3419.4855 / 22.7Yes
5555272D structurepropranololC16H21NO2259.3493 / 23.0Yes
126322D structureCHEMBL62033C24H24N4O3416.4815 / 12.5Yes
136862D structure8-OH-DpatC16H25NO247.3822 / 14.1Yes
139782D structureCHEMBL57364C21H28ClN3O2389.9244 / 03.5Yes
142292D structure180083-23-2C32H32N4O3520.6336 / 05.6No
146842D structureCHEMBL302882C21H19Br3N4O583.1223 / 44.6No
149732D structureCHEMBL434591C25H25N3O3S447.5535 / 14.2Yes
4422322D structureEMETINEC29H40N2O4480.6496 / 14.7Yes
152632D structureCHEMBL356799C25H31FN4O422.5483 / 13.9Yes
152872D structureCHEMBL1256344C34H40N4O6600.7168 / 14.2No
153402D structureCHEMBL291305C26H32N2O4436.5525 / 03.5Yes
153592D structureCHEMBL95251C19H31NO2305.4623 / 14.0Yes
4648092D structureCHEMBL3609357C24H29N3359.5172 / 14.1Yes
159232D structureCHEMBL40819C25H24N4O5S492.557 / 14.0Yes
166012D structureCHEMBL253233C29H30N4OS482.6465 / 15.7No
166922D structureCHEMBL303988C25H31N3O4437.546 / 13.4Yes
167812D structurePipamperoneC21H30FN3O2375.4885 / 12.0Yes
169882D structureMetrenperoneC24H26FN3O2407.4895 / 02.7Yes
171122D structureSCHEMBL977787C22H35Cl2N7O2500.4697 / 23.2No
171492D structureCHEMBL2440659C15H11FN4O2S330.3377 / 12.4Yes
178802D structureBmy-7378C22H31N3O3385.5085 / 02.8Yes
191432D structureCHEMBL1255003C25H29NO3391.5114 / 15.3No
4424222D structureCHEMBL3415013C25H32N4O2420.5574 / 23.5Yes
201932D structureimipramineC19H24N2280.4152 / 04.8Yes
215422D structureCHEMBL40780C26H24N4O3S472.5636 / 13.9Yes
216002D structureCHEMBL14213C26H28N4O3S476.5956 / 04.1Yes
229602D structureCHEMBL382972C26H31NO5437.5366 / 14.9Yes
230142D structureCHEMBL417890C25H25N3O4431.4925 / 13.5Yes
232282D structureCHEMBL43345C17H17NO2267.3283 / 32.5Yes
233522D structuresulpirideC15H23N3O4S341.4266 / 20.6Yes
5555732D structurePhenethylamineC8H11N121.1831 / 11.4Yes
4426072D structureCHEMBL3342872C23H31N3O5S2493.6379 / 02.7Yes
250502D structureCHEMBL42231C27H31NO3417.5494 / 15.5No
251492D structureCHEMBL340641C24H26Cl2N4O457.3994 / 15.3No
4426902D structureLISURIDEC20H26N4O338.4552 / 22.7Yes
265532D structureRauwolscineC21H26N2O3354.454 / 22.9Yes
265972D structureYohimbineC21H26N2O3354.454 / 22.9Yes
266362D structureCHEBI:48565C21H26N2O3354.454 / 22.9Yes
4427132D structureterconazoleC26H31Cl2N5O3532.4667 / 04.8No
283232D structureCHEMBL252031C25H30N4OS434.6025 / 14.6Yes
293682D structureCHEMBL2153559C20H25NO6375.4217 / 12.9Yes
4428222D structureCHEMBL3415017C23H27BrN4O2471.3994 / 24.3Yes
301252D structureCHEMBL495289C25H27NO3389.4954 / 14.0Yes
301622D structureMetopimazineC22H27N3O3S2445.5966 / 13.1Yes
302532D structureCHEMBL111372C14H17N3O3S307.3685 / 31.4Yes
4428422D structureCHEMBL3342856C19H29N3O3347.4596 / 11.4Yes
303412D structureCHEMBL293539C21H27ClFN3O2407.9145 / 03.6Yes
4428682D structureCHEMBL3342855C19H28N2O5S396.5027 / 01.2Yes
315832D structureCHEMBL89380C21H34N4O358.535 / 03.0Yes
327792D structureCHEMBL144901C25H29FN4O420.5323 / 13.7Yes
333922D structureCHEMBL420510C26H32N4O2432.5684 / 03.8Yes
4429942D structureCHEMBL3342866C25H33N3O5S487.6158 / 02.7Yes
342132D structureCHEMBL58384C21H27ClIN3O2515.824 / 04.1No
4430242D structureCHEMBL3342873C20H31N3O5S425.5448 / 01.1Yes
345832D structureCHEMBL58803C23H28N4O376.5043 / 14.0Yes
349292D structureCHEMBL385371C26H30ClNO4455.9795 / 2N/AN/A
358012D structureCHEMBL299454C21H30ClN3O375.9413 / 04.1Yes
5556142D structureTetryzolineC13H16N2200.2851 / 11.8Yes
362032D structureCHEMBL144710C25H31FN4O422.5483 / 13.9Yes
371032D structureCHEMBL2115086C21H23N3O3S397.4935 / 12.8Yes
371062D structureCHEMBL291839C21H23N3O3S397.4935 / 12.8Yes
374512D structureCHEMBL313990C23H24ClN3O5S489.9716 / 03.6Yes
4431872D structurePecazineC19H22N2S310.4593 / 05.6No
381152D structureReboxetineC19H23NO3313.3974 / 13.0Yes
382452D structureCHEMBL541129C21H32Cl2FN3416.4063 / 3N/AN/A
393002D structureCHEMBL61598C25H28N4O4448.5235 / 22.0Yes
395492D structureCHEMBL99503C17H26BrNO2356.3043 / 13.6Yes
409782D structureCHEMBL145384C26H34ClN5O3500.047 / 14.6No
411102D structureCHEMBL1946781C28H29NO6475.5417 / 3N/AN/A
416982D structureL-765314C27H34N6O5522.6069 / 23.1No

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