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Name | Metabotropic glutamate receptor 2 |
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Species | Homo sapiens (Human) |
Gene | GRM2 |
Synonym | mGluR2 mGlu2 receptor metabotropic glutamate receptor 2 GPRC1B glutamate receptor |
Disease | Central nervous system disease Anxiety disorder Bipolar disorder Major depressive disorder Mood disorder [ Show all ] |
Length | 872 |
Amino acid sequence | MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL |
UniProt | Q14416 |
Protein Data Bank | 5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 5cnj. |
BioLiP | BL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443 |
Therapeutic Target Database | T62820 |
ChEMBL | CHEMBL5137 |
IUPHAR | 290 |
DrugBank | N/A |
Name | CHEMBL242344 |
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Molecular formula | C12H19N3O3 |
IUPAC name | 2-amino-2-[5-(cyclohexylmethyl)-1-hydroxypyrazol-4-yl]acetic acid |
Molecular weight | 253.302 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | -0.3 |
Synonyms | BDBM50208757 (RS)-2-amino-(5-cyclohexylmethyl-1-hydroxy-4-pyrazolyl)acetic acid |
Inchi Key | CARPBCWTCPQWEH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H19N3O3/c13-11(12(16)17)9-7-14-15(18)10(9)6-8-4-2-1-3-5-8/h7-8,11,18H,1-6,13H2,(H,16,17) |
PubChem CID | 16739377 |
ChEMBL | CHEMBL242344 |
IUPHAR | N/A |
BindingDB | 50208757 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 32000.0 nM | PMID17376693 | BindingDB |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218