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Name | Substance-P receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Tacr1 |
Synonym | TAC1R Substance P receptor SPR NK1R NK1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 407 |
Amino acid sequence | MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA |
UniProt | P14600 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4027 |
IUPHAR | 360 |
DrugBank | N/A |
Name | CHEMBL3596495 |
---|---|
Molecular formula | C30H29F3N2O |
IUPAC name | 4-[3-[(1-cyclopropyl-4-phenylpiperidin-4-yl)methoxymethyl]-5-(trifluoromethyl)phenyl]benzonitrile |
Molecular weight | 490.57 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 6.6 |
Synonyms | JJSFBTVUNKEJKM-UHFFFAOYSA-N 3'-(((1-Cyclopropyl-4-phenylpiperidin-4-yl)methoxy)methyl)-5'-(trifluoromethyl)biphenyl-4-carbonitrile SCHEMBL3597292 BDBM50106368 |
Inchi Key | JJSFBTVUNKEJKM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C30H29F3N2O/c31-30(32,33)27-17-23(16-25(18-27)24-8-6-22(19-34)7-9-24)20-36-21-29(26-4-2-1-3-5-26)12-14-35(15-13-29)28-10-11-28/h1-9,16-18,28H,10-15,20-21H2 |
PubChem CID | 58993542 |
ChEMBL | CHEMBL3596495 |
IUPHAR | N/A |
BindingDB | 50106368 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 1.8 nM | PMID26048800 | BindingDB |
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