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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	P2Y purinoceptor 14
Species	Homo sapiens (Human)
Gene	P2RY14
Synonym	G-protein coupled receptor 105 GPR105 G protein-coupled receptor 105 P2Y purinoceptor 14 P2Y14 P2Y14 receptor purinergic receptor P2Y G protein coupled receptor for UDP-glucose UDP-glucose receptor [ Show all ]
Disease	N/A
Length	338
Amino acid sequence	MINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProt	Q15391
Protein Data Bank	N/A
GPCR-HGmod model	Q15391
3D structure model	This predicted structure model is from GPCR-EXP Q15391.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4518
IUPHAR	330
DrugBank	N/A

Ligand

Name	CHEMBL439378
Molecular formula	C16H28N2O16P2S
IUPAC name	[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-methylsulfanyl-2-oxo-1,6-dihydropyrimidin-3-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] hydrogen phosphate
Molecular weight	598.406
Hydrogen bond acceptor	17
Hydrogen bond donor	9
XlogP	-5.5
Synonyms	BDBM50209664 diphosphoric acid 1-alpha-D-glucopyranosyl ester 2-((4''-methylthio)uridin-5''''-yl) ester
Inchi Key	AHJZJKHBHBHIPP-DKBMREHESA-N
Inchi ID	InChI=1S/C16H28N2O16P2S/c1-37-8-2-3-18(16(25)17-8)14-12(23)10(21)7(31-14)5-30-35(26,27)34-36(28,29)33-15-13(24)11(22)9(20)6(4-19)32-15/h2-3,6-15,19-24H,4-5H2,1H3,(H,17,25)(H,26,27)(H,28,29)/t6-,7-,8?,9-,10-,11+,12-,13-,14-,15-/m1/s1
PubChem CID	44422868
ChEMBL	CHEMBL439378
IUPHAR	N/A
BindingDB	50209664
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID17407275	BindingDB,ChEMBL

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