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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Free fatty acid receptor 1
Species	Rattus norvegicus (Rat)
Gene	Ffar1
Synonym	FFA1 receptor FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40
Disease	N/A for non-human GPCRs
Length	300
Amino acid sequence	MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK
UniProt	Q8K3T4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1795180
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL17418721
Molecular formula	C33H39FN2O6
IUPAC name	(3S)-3-cyclopropyl-3-[3-[[5-(2-fluoro-5-methoxyphenyl)-6-(2,2,6,6-tetramethyloxan-4-yl)oxypyrazin-2-yl]methoxy]phenyl]propanoic acid
Molecular weight	578.681
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	5.6
Synonyms	BDBM168165 US9688642, 26 (3S)-3-Cyclopropyl-3-(3-((5-(2-fluoro-5-methoxyphenyl)-6-(2,2,6,6-tetramethyl-tetrahydro-2H-pyran-4-yloxy)pyrazin-2-yl)methoxy)phenyl)propanoic acid MRBDSBIVJCROCF-SANMLTNESA-N
Inchi Key	MRBDSBIVJCROCF-SANMLTNESA-N
Inchi ID	InChI=1S/C33H39FN2O6/c1-32(2)16-25(17-33(3,4)42-32)41-31-30(27-14-23(39-5)11-12-28(27)34)35-18-22(36-31)19-40-24-8-6-7-21(13-24)26(15-29(37)38)20-9-10-20/h6-8,11-14,18,20,25-26H,9-10,15-17,19H2,1-5H3,(H,37,38)/t26-/m0/s1
PubChem CID	118645505
ChEMBL	N/A
IUPHAR	N/A
BindingDB	168165
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	110.0 nM	N/A	BindingDB

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