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GPCR

NameMuscarinic acetylcholine receptor M4
SpeciesHomo sapiens (Human)
GeneCHRM4
SynonymChrm-4
M4 receptor
cholinergic receptor
cholinergic receptor, muscarinic 4
HM3
DiseaseOrganophosphate poisoning
Overactive bladder disorder; Spasm
Parkinson's disease
Peptic ulcer
Peptic ulcer disease; Irritable bowel syndrome; Pancreatitis; Gastritis
[ Show all ]
Length479
Amino acid sequenceMANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProtP08173
Protein Data Bank5dsg
GPCR-HGmod modelP08173
3D structure modelThis structure is from PDB ID 5dsg.
BioLiPBL0339919,BL0339921, BL0339920
Therapeutic Target DatabaseT20709, T50918
ChEMBLCHEMBL1821
IUPHAR16
DrugBankBE0000405

Ligand

Namecinnarizine
Molecular formulaC26H28N2
IUPAC name1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine
Molecular weight368.524
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP5.8
SynonymsStugeron
298-57-7
Dimitronal
Stutgin
Dimitron
[ Show all ]
Inchi KeyDERZBLKQOCDDDZ-JLHYYAGUSA-N
Inchi IDInChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+
PubChem CID1547484
ChEMBLCHEMBL43064
IUPHARN/A
BindingDB50017657
DrugBankDB00568

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC503660.0 nMDrugMatrix in vitro pharmacology dataChEMBL
Ki510.0 nMDrugMatrix in vitro pharmacology dataChEMBL

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