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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameMuscarinic acetylcholine receptor M4
SpeciesHomo sapiens (Human)
GeneCHRM4
SynonymChrm-4
M4 receptor
cholinergic receptor
cholinergic receptor, muscarinic 4
HM3
DiseaseOrganophosphate poisoning
Overactive bladder disorder; Spasm
Parkinson's disease
Peptic ulcer
Peptic ulcer disease; Irritable bowel syndrome; Pancreatitis; Gastritis
[ Show all ]
Length479
Amino acid sequenceMANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
UniProtP08173
Protein Data Bank5dsg
GPCR-HGmod modelP08173
3D structure modelThis structure is from PDB ID 5dsg.
BioLiPBL0339919,BL0339921, BL0339920
Therapeutic Target DatabaseT20709, T50918
ChEMBLCHEMBL1821
IUPHAR16
DrugBankBE0000405

Known ligands

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Total entries: 1403
Page:  / 15 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
4416772D structureCHEMBL1602658C23H28N2O5S444.5466 / 02.6Yes
5262D structureCHEMBL2407175C24H36N4O3428.5775 / 02.7Yes
10092D structureCHEMBL2205816C18H20N2O280.3713 / 11.8Yes
12762D structureCHEMBL141736C24H29N2O2+377.5082 / 02.8Yes
19422D structureCHEMBL282874C20H20N2O304.3932 / 13.5Yes
22722D structure1-(cyclohexylmethyl)pyrrolidineC11H21N167.2961 / 03.1Yes
29092D structureCHEMBL282680C19H18N2O2306.3653 / 12.6Yes
30622D structureGenostrychnineC21H22N2O3350.4183 / 01.4Yes
31372D structureAC1N0YGAC3H7NO4S153.1525 / 2-4.7Yes
36562D structureCHEMBL23620C23H23N3O3389.4554 / 11.7Yes
38482D structureCEP-11981C28H27N7O477.5725 / 23.9Yes
40102D structureCHEMBL215894C37H41Cl3N4O4712.1095 / 35.9No
43172D structuresulconazoleC18H15Cl3N2S397.7422 / 06.1No
49892D structureCHEMBL255692C36H46Cl2N2O2609.6764 / 4N/ANo
57532D structureAHOUBRCZNHFOSL-UHFFFAOYSA-NC19H20FNO3329.3715 / 13.5Yes
57632D structureparoxetineC19H20FNO3329.3715 / 13.5Yes
5532732D structureWIN-51708C29H33N3O439.6033 / 16.5No
63312D structureBDBM86295C12H16N3O2+234.2792 / 00.0Yes
66062D structurecarbacholC6H15ClN2O2182.6483 / 1N/AN/A
66822D structureCHEMBL214029C38H43F3N4O4676.7818 / 34.7No
68342D structureCID 49797317C14H18N2O6310.3068 / 2N/AN/A
4637342D structureCHEMBL3633757C26H24BrNO4494.3855 / 05.4No
71892D structureCHEMBL2024331C23H33N3O3399.5354 / 13.6Yes
5216642D structureCHEMBL3808947C22H29N5S395.5696 / 05.4No
76552D structureCHEMBL84113C14H17NO2231.2953 / 12.5Yes
77782D structureCHEMBL376295C19H25N5O5S2467.55912 / 02.8No
5217142D structureCHEMBL3808592C21H24N4O3S2444.5687 / 13.3Yes
95352D structureGlycopyrroniumC19H28NO3+318.4373 / 13.1Yes
98662D structureAC-42C20H31NO301.4742 / 05.2No
99102D structureCHEMBL403773C42H52N2O2616.894 / 27.9No
101722D structureCHEMBL194206C23H30FN5O2427.5246 / 12.7Yes
103912D structureN-Allyl Brucine IodideC26H31N2O4+435.5444 / 01.6Yes
107082D structureCHEMBL213709C39H45F3N4O4690.8088 / 25.1No
107212D structureCHEMBL3287723C25H32O7444.5247 / 25.7No
109142D structureCHEMBL169494C19H22N2278.3992 / 02.4Yes
119182D structureCHEMBL477821C24H29ClN4O424.9733 / 14.1Yes
125442D structureCHEMBL593620C11H24INO2329.2223 / 0N/AN/A
125492D structureCHEMBL593685C11H24INO2329.2223 / 0N/AN/A
127032D structureCHEMBL1083925C20H22ClFN2O360.8573 / 24.3Yes
128192D structureCHEMBL85190C15H19NO2245.3223 / 03.0Yes
133092D structureAclidiniumC26H30NO4S2+484.6496 / 14.7Yes
137812D structureCHEMBL557808C19H30INO2S463.4184 / 0N/AN/A
140032D structureCHEMBL1922764C19H20ClNO2329.8243 / 05.7No
151532D structurecremastrineC14H25NO3255.3584 / 12.2Yes
154302D structureCHEMBL568775C23H32NO2+354.5142 / 14.4Yes
154342D structureCHEMBL569089C23H32NO2+354.5142 / 14.4Yes
154382D structureCHEMBL569307C23H32NO2+354.5142 / 14.4Yes
154452D structureCHEMBL568870C23H32NO2+354.5142 / 14.4Yes
154512D structureCHEMBL569760C23H32NO2+354.5142 / 14.4Yes
154712D structureCHEMBL2205829C19H19NO3309.3654 / 12.2Yes
157832D structureCID 44448670C21H28ClNO345.9112 / 2N/AN/A
4422632D structureCHEMBL3354075C26H42N2O2414.6343 / 15.7No
5219532D structureAM-0902C17H15ClN6O2370.7976 / 02.3Yes
165742D structureCHEMBL2059306C24H28N4O2404.5143 / 13.8Yes
201772D structureimipramineC19H24N2280.4152 / 04.8Yes
205432D structureAQ-RA 741C27H37N5O2463.6265 / 13.1Yes
5365012D structureCHEMBL3974708C17H18N4O3S2390.4767 / 22.2Yes
209752D structureCHEMBL62247C24H26N2O4406.4825 / 14.2Yes
216282D structureAC1L7RMRC20H25NO2S343.4854 / 14.0Yes
220692D structureCHEMBL568775C23H32INO2481.4183 / 1N/AN/A
220742D structureCHEMBL569760C23H32INO2481.4183 / 1N/AN/A
220762D structureCHEMBL569089C23H32INO2481.4183 / 1N/AN/A
220802D structureCHEMBL568870C23H32INO2481.4183 / 1N/AN/A
220892D structureCHEMBL569307C23H32INO2481.4183 / 1N/AN/A
5221282D structureCHEMBL3775436C15H26ClNO3303.8274 / 3N/AN/A
5221812D structureCHEMBL3775769C15H26ClNO3303.8274 / 3N/AN/A
221792D structuresuloctidilC20H35NOS337.5663 / 25.8No
222432D structureCHEMBL2111540C25H31N3O2S437.6026 / 04.1Yes
222452D structureCHEMBL2114066C25H31N3O2S437.6026 / 04.1Yes
225502D structureCHEMBL283036C19H19F3N4360.3846 / 13.6Yes
228732D structuretropicamideC17H20N2O2284.3593 / 11.5Yes
235782D structureCHEMBL378872C37H41Cl3N4O4712.1095 / 35.9No
245952D structureCHEMBL262198C24H27NO6425.4817 / 2N/AN/A
246362D structureCHEMBL540316C23H28ClNO2385.9323 / 1N/AN/A
255332D structureCHEMBL2313391C18H16ClN3O3S389.8546 / 24.4Yes
258012D structureCHEMBL2042406C20H26INO2439.3373 / 0N/AN/A
258062D structureCHEMBL2042405C20H26INO2439.3373 / 0N/AN/A
258082D structureCHEMBL2042404C20H26INO2439.3373 / 0N/AN/A
5223542D structureCHEMBL1314270C20H20Cl2N4OS435.3675 / 15.4No
263822D structureCHEMBL105122C23H24N2O3S408.5165 / 14.4Yes
264392D structureCHEMBL304036C23H24N2O3376.4564 / 14.3Yes
264532D structureCHEMBL1202234C29H31BrN2O2519.4833 / 0N/ANo
265262D structureCHEMBL2042553C21H25NO6387.4327 / 2N/AN/A
265282D structureCHEMBL2042554C21H25NO6387.4327 / 2N/AN/A
265352D structureCHEMBL2042552C21H25NO6387.4327 / 2N/AN/A
269382D structureterconazoleC26H31Cl2N5O3532.4667 / 04.8No
272032D structureCHEMBL2203713C18H22N4S326.4624 / 22.9Yes
272672D structureCHEMBL315428C14H16N2O4276.2925 / 12.3Yes
274952D structureCHEMBL2432063C19H29N271.4481 / 04.7Yes
283602D structureCHEMBL593685C11H24NO2+202.3182 / 00.9Yes
283622D structureCHEMBL593620C11H24NO2+202.3182 / 00.9Yes
285242D structureCHEMBL197796C24H33N5O2S455.6216 / 13.1Yes
286202D structureCHEMBL352779C20H23N3O321.4243 / 12.2Yes
288712D structureCHEMBL280340C22H24N2O3364.4454 / 13.4Yes
289412D structureCHEMBL2407171C20H28N4O4388.4686 / 11.7Yes
296032D structureCHEMBL2336054C21H29N3O3371.4814 / 02.2Yes
296092D structureCHEMBL2336055C21H29N3O3371.4814 / 02.2Yes
310772D structureCHEMBL105674C22H21ClN2O3396.8714 / 14.5Yes
318132D structureCP-810123C14H18N4O258.3255 / 02.2Yes
319762D structureCHEMBL170088C22H28N2320.482 / 03.6Yes

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