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GPCR

NameC5a anaphylatoxin chemotactic receptor 1
SpeciesHomo sapiens (Human)
GeneC5AR1
SynonymCD88
complement component 5a receptor 1
C5a anaphylatoxin chemotactic receptor
C5aR1
C5R1
[ Show all ]
DiseaseVasculitis
Rheumatoid arthritis
Inflammatory disease
Atopic dermatitis
Length350
Amino acid sequenceMDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
UniProtP21730
Protein Data Bank6c1q, 6c1r, 5o9h
GPCR-HGmod modelP21730
3D structure modelThis structure is from PDB ID 6c1q.
BioLiPBL0415512, BL0415513, BL0415514, BL0401194,BL0401195,BL0401196,, BL0415511
Therapeutic Target DatabaseT15439
ChEMBLCHEMBL2373
IUPHAR32
DrugBankN/A

Ligand

NameCHEMBL82917
Molecular formulaC19H27N3O
IUPAC name4-amino-2-methyl-N-octylquinoline-6-carboxamide
Molecular weight313.445
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP4.6
SynonymsSCHEMBL8353636
4-Amino-2-methyl-N-octylquinoline-6-carboxamide
Inchi KeyDGLZIDKXVUTQLC-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H27N3O/c1-3-4-5-6-7-8-11-21-19(23)15-9-10-18-16(13-15)17(20)12-14(2)22-18/h9-10,12-13H,3-8,11H2,1-2H3,(H2,20,22)(H,21,23)
PubChem CID15133396
ChEMBLCHEMBL82917
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<100.0 ug.mL-1PMID1310118ChEMBL

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