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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW/RWplus HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameC5a anaphylatoxin chemotactic receptor 1
SpeciesHomo sapiens (Human)
GeneC5AR1
SynonymCD88
complement component 5a receptor 1
C5a anaphylatoxin chemotactic receptor
C5aR1
C5R1
[ Show all ]
DiseaseVasculitis
Rheumatoid arthritis
Inflammatory disease
Atopic dermatitis
Length350
Amino acid sequenceMDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
UniProtP21730
Protein Data Bank6c1q, 6c1r, 5o9h
GPCR-HGmod modelP21730
3D structure modelThis structure is from PDB ID 6c1q.
BioLiPBL0415512, BL0415513, BL0415514, BL0401194,BL0401195,BL0401196,, BL0415511
Therapeutic Target DatabaseT15439
ChEMBLCHEMBL2373
IUPHAR32
DrugBankN/A

Known ligands

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Total entries: 690
Page:  / 7 

GLASS IDMoleculeFormulaMolecular weightH-bond acceptor / donorXlogPLipinski's druglikeness
23692D structureCHEMBL441393C52H87N15O15S1194.4219 / 17-7.6No
24172D structureCHEMBL117751C44H65N11O7860.07410 / 10-0.6No
38232D structureCHEMBL481755C27H29F3N2O454.5376 / 17.3No
44242D structureCHEMBL261594C31H36N2O3484.645 / 06.1No
49252D structureCHEMBL435777C45H63N11O6854.078 / 93.0No
49262D structureCHEMBL293241C45H63N11O6854.078 / 93.0No
58772D structurediamide 7C22H22N2O3S394.4894 / 34.8Yes
59212D structureCHEMBL3646994C29H34N4438.6193 / 16.8No
63652D structuremethionine benzimidazole 6C23H25N3O3S423.5315 / 24.8Yes
86322D structureCHEMBL425289C50H68N8O7893.1437 / 77.2No
88212D structureCHEMBL3646909C24H28N4372.5164 / 05.1No
90472D structureCHEMBL339127C43H77N13O12S1000.2316 / 14-6.2No
4593002D structureBDBM50290481C30H44N6O3536.7214 / 44.1No
106342D structureCHEMBL408929C59H98N18O18S1379.622 / 20-9.6No
108212D structureCHEMBL479540C28H34N2O414.5933 / 17.2No
108412D structureCHEMBL479557C26H31N3O2417.5535 / 25.0Yes
112812D structureCHEMBL3647016C29H36N6O484.6486 / 25.3No
134702D structureISHKDMQLGRC49H85N17O15S1184.3820 / 18-9.4No
148192D structureCHEMBL3646995C29H36N2412.6212 / 07.7No
5480522D structureCHEMBL3985025C32H41FN8O572.7338 / 15.3No
5576822D structureSCHEMBL14663067C32H41FN8O572.7338 / 15.3No
150022D structureCHEMBL3647034C25H26N4O398.514 / 14.9Yes
156772D structureCHEMBL412249C53H80N14O15S1185.3719 / 16-7.1No
173432D structureCHEMBL521090C27H31N3O2429.5644 / 25.8No
5480952D structureCHEMBL3963795C34H42N6O550.7516 / 15.9No
5577852D structureSCHEMBL14663100C34H42N6O550.7516 / 15.9No
183562D structureCHEMBL512543C27H32FN3O6513.5668 / 23.0No
184772D structureCHEMBL261966C58H89N15O16S1284.520 / 17-7.0No
5578282D structureSCHEMBL14671793C34H44N6O552.7676 / 17.1No
4651422D structureCHEMBL3646936C34H44N6O552.7676 / 17.1No
5481032D structureCHEMBL3968102C30H32F3N7O563.6299 / 24.6No
5578392D structureSCHEMBL14662831C30H32F3N7O563.6299 / 24.6No
195462D structureCHEMBL465377C30H32ClNO5522.0385 / 06.3No
214132D structureCHEMBL3647040C27H30N4410.5653 / 15.8No
218012D structureCHEMBL86661C20H17ClN2O2352.8183 / 14.5Yes
5579812D structureSCHEMBL14671748C33H41N5O523.7255 / 16.8No
4657082D structureCHEMBL3646919C33H41N5O523.7255 / 16.8No
5481422D structureCHEMBL3969992C33H41N5O523.7255 / 16.8No
234592D structureCHEMBL410927C27H32N2O400.5663 / 06.5No
239622D structureCHEMBL437988C46H61ClN8O7873.4938 / 74.4No
247162D structureCHEMBL259645C29H33FN2O444.5944 / 06.4No
5580612D structureSCHEMBL14663204C30H35ClN6O531.1016 / 16.2No
5481702D structureCHEMBL3897947C30H35ClN6O531.1016 / 16.2No
4594442D structureBDBM50290485C29H36N6O4532.6455 / 52.2No
297822D structureCID 44309234C35H40N6O3592.7444 / 34.3No
298982D structureCHEMBL456053C26H25ClN2O2S465.0084 / 05.9No
304612D structureCHEMBL261276C33H38N2O478.683 / 08.5No
5482212D structureCHEMBL3936892C31H38N6O510.6866 / 16.0No
5582142D structureSCHEMBL14663226C31H38N6O510.6866 / 16.0No
316122D structureCHEMBL173708C22H23N3O2361.4453 / 23.8Yes
5582612D structureSCHEMBL14671799C33H42N6O538.746 / 16.7No
5482572D structureCHEMBL3899595C33H42N6O538.746 / 16.7No
345382D structureCHEMBL472051C21H23FN2O2354.4253 / 13.8Yes
358302D structureCHEMBL2372061C39H66N8O13855.015 / 71.7No
373292D structureCHEMBL87699C19H19N3O305.3813 / 23.0Yes
380092D structureCHEMBL460167C28H27ClN2O2458.9863 / 06.1No
389432D structureCHEMBL3646988C27H32N2384.5672 / 06.9No
4432282D structureCHEMBL3350664C54H72N14O151157.2518 / 17-3.4No
392382D structureCHEMBL58781C44H59N11O7854.0268 / 92.2No
406612D structureCHEMBL519540C25H26ClNO3S455.9974 / 05.7No
5585342D structureSCHEMBL15105200C31H40N8O540.7167 / 14.9No
5483512D structureCHEMBL3895276C31H40N8O540.7167 / 14.9No
4680382D structureCHEMBL3647020C33H43N7O553.7557 / 15.7No
423392D structureCHEMBL315307C21H18N4O342.4023 / 23.8Yes
426652D structureCHEMBL261277C32H36N2O2480.6524 / 07.7No
427102D structureCHEMBL405647C46H63N9O7854.0668 / 83.9No
430362D structureCHEMBL514743C27H27ClN2O2S479.0354 / 06.3No
433832D structureCHEMBL414361C58H88N14O15S1253.4819 / 15-5.5No
5586312D structureSCHEMBL14660667C29H40N6O488.686 / 05.4No
5483922D structureCHEMBL3889744C29H40N6O488.686 / 05.4No
4684252D structureCHEMBL3646911C33H41N5O523.7255 / 26.7No
454642D structureCHEMBL408432C32H36N2S480.7143 / 08.7No
468192D structureCHEMBL2372064C44H74N8O14939.11816 / 72.6No
472662D structureCHEMBL409045C48H63N9O7878.0888 / 83.6No
475372D structureCHEMBL353857C22H29N3O2367.4933 / 24.5Yes
483102D structureCHEMBL85288C20H16F3N3O371.3636 / 24.1Yes
496672D structureCHEMBL169297C21H20FN3O349.4093 / 23.9Yes
500632D structureCHEMBL259971C32H36N2O464.6533 / 08.1No
520762D structureCHEMBL481357C27H33N3O415.5814 / 25.8No
523172D structureCHEMBL538918C27H32ClN3O450.0233 / 27.9No
536452D structureCHEMBL1170025C76H123N17O20S21659.0424 / 210.3No
555172D structureCHEMBL520426C28H33ClN2O449.0353 / 07.5No
4700982D structureCHEMBL3647026C28H33ClN8O533.0777 / 14.4No
581742D structureCHEMBL513247C26H27ClN2O3450.9634 / 04.9Yes
583022D structureCHEMBL2372087C45H70N8O13931.09815 / 73.2No
587632D structureCID 44309036C33H38N6O3566.7064 / 33.9No
593962D structureCHEMBL82917C19H27N3O313.4453 / 24.6Yes
595762D structureCHEMBL259642C31H34N2O450.6263 / 07.7No
613862D structureCHEMBL467571C28H37ClN2O3485.0654 / 05.6No
617462D structureCHEMBL267491C41H61N11O7820.0098 / 91.7No
621212D structureCHEMBL409128C29H33ClN2O461.0463 / 06.9No
627852D structureBDBM50290463C28H43N7O3525.6985 / 43.2No
636322D structureCHEMBL217053C18H13BrN2O4401.2165 / 13.5Yes
636922D structureCHEMBL408796C55H88N14O131153.3916 / 16-1.8No
5486432D structureCHEMBL3971727C33H42N4O2526.7256 / 06.2No
5592582D structureSCHEMBL14660427C33H42N4O2526.7256 / 06.2No
643562D structureCHEMBL488389C23H28ClN3O3429.9455 / 14.5Yes
650432D structureCHEMBL480892C29H36N2O2444.6194 / 06.9No
653022D structureCHEMBL305486C29H45N7O3539.7255 / 33.7No
653432D structureCHEMBL2373534C47H69N11O7900.13910 / 101.2No

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