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GPCR

NameD(1A) dopamine receptor
SpeciesBos taurus (Bovine)
GeneDRD1
SynonymDopamine D1 receptor
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLGKTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProtQ95136
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2967
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL165171
Molecular formulaC29H33N
IUPAC name4-(1,5-diphenylpenta-1,4-diyn-3-ylidene)-N,N-dipropylcyclohexan-1-amine
Molecular weight395.59
Hydrogen bond acceptor1
Hydrogen bond donor0
XlogP7.8
SynonymsBDBM50085334
[4-(3-Phenyl-1-phenylethynyl-prop-2-ynylidene)-cyclohexyl]-dipropyl-amine
Inchi KeyDVRQBYGOXHPKHC-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H33N/c1-3-23-30(24-4-2)29-21-19-28(20-22-29)27(17-15-25-11-7-5-8-12-25)18-16-26-13-9-6-10-14-26/h5-14,29H,3-4,19-24H2,1-2H3
PubChem CID10524751
ChEMBLCHEMBL165171
IUPHARN/A
BindingDB50085334
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki2200.0 nMPMID10691700BindingDB,ChEMBL

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