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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL347663
Molecular formula	C25H23ClN2O
IUPAC name	4-[5-(4-chlorophenyl)-3-[2-(2-methylpropoxy)phenyl]-1H-pyrrol-2-yl]pyridine
Molecular weight	402.922
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	6.5
Synonyms	BDBM50075752 4-[5-(4-Chloro-phenyl)-3-(2-isobutoxy-phenyl)-1H-pyrrol-2-yl]-pyridine 2-(4-Pyridinyl)-3-(2-isobutoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrole
Inchi Key	FFRLVMNTSSMAOD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H23ClN2O/c1-17(2)16-29-24-6-4-3-5-21(24)22-15-23(18-7-9-20(26)10-8-18)28-25(22)19-11-13-27-14-12-19/h3-15,17,28H,16H2,1-2H3
PubChem CID	44373192
ChEMBL	CHEMBL347663
IUPHAR	N/A
BindingDB	50075752
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3.0 nM	PMID10201821	BindingDB,ChEMBL
IC50	200.0 nM	PMID10201821	BindingDB,ChEMBL
IC50	3767.0 nM	N/A	BindingDB
IC50	3767.04 nM	Med Chem Res, (2013) None:None:1	ChEMBL

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