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Name | Type-1 angiotensin II receptor |
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Species | Homo sapiens (Human) |
Gene | AGTR1 |
Synonym | Type-1 angiotensin II receptor HAT1R Agtr-1a type-1A angiotensin II receptor AT1 [ Show all ] |
Disease | Metabolic syndrome x Myocardial infarction Hypertension Restenosis Alzheimer disease [ Show all ] |
Length | 359 |
Amino acid sequence | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE |
UniProt | P30556 |
Protein Data Bank | 6do1, 4zud, 4yay |
GPCR-HGmod model | P30556 |
3D structure model | This structure is from PDB ID 6do1. |
BioLiP | BL0312790, BL0326733, BL0439004,BL0439005 |
Therapeutic Target Database | T74456 |
ChEMBL | CHEMBL227 |
IUPHAR | 34 |
DrugBank | BE0000062 |
Name | CHEMBL309081 |
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Molecular formula | C43H39N7O3 |
IUPAC name | [4-(diphenylcarbamoyl)phenyl]methyl 5-ethyl-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate |
Molecular weight | 701.831 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 8.7 |
Synonyms | BDBM50283193 5-Ethyl-2-propyl-3-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid 4-diphenylcarbamoyl-benzyl ester |
Inchi Key | FKCMDMVCVNAORO-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C43H39N7O3/c1-3-13-39-44-38(4-2)40(49(39)28-30-20-24-32(25-21-30)36-18-11-12-19-37(36)41-45-47-48-46-41)43(52)53-29-31-22-26-33(27-23-31)42(51)50(34-14-7-5-8-15-34)35-16-9-6-10-17-35/h5-12,14-27H,3-4,13,28-29H2,1-2H3,(H,45,46,47,48) |
PubChem CID | 44311406 |
ChEMBL | CHEMBL309081 |
IUPHAR | N/A |
BindingDB | 50283193 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 20.0 nM | , Bioorg. Med. Chem. Lett., (1994) 4:18:2235 | BindingDB,ChEMBL |
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