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GPCR

NameD(1A) dopamine receptor
SpeciesBos taurus (Bovine)
GeneDRD1
SynonymDopamine D1 receptor
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLGKTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProtQ95136
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2967
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL485499
Molecular formulaC19H21BrN4
IUPAC name4-bromo-6-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-benzimidazole
Molecular weight385.309
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.1
Synonyms4-Bromo-6-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-benzimidazole
BDBM50264512
Inchi KeyFNBRMLSEYFMCPO-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H21BrN4/c20-17-12-15(13-18-19(17)22-14-21-18)6-7-23-8-10-24(11-9-23)16-4-2-1-3-5-16/h1-5,12-14H,6-11H2,(H,21,22)
PubChem CID25105245
ChEMBLCHEMBL485499
IUPHARN/A
BindingDB50264512
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<1000.0 nMPMID18006194BindingDB,ChEMBL

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