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Name | Alpha-2C adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRA2C |
Synonym | alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I [ Show all ] |
Disease | Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease [ Show all ] |
Length | 462 |
Amino acid sequence | MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ |
UniProt | P18825 |
Protein Data Bank | N/A |
GPCR-HGmod model | P18825 |
3D structure model | This predicted structure model is from GPCR-EXP P18825. |
BioLiP | N/A |
Therapeutic Target Database | T01777 |
ChEMBL | CHEMBL1916 |
IUPHAR | 27 |
DrugBank | BE0004864, BE0000342, BE0004888 |
Name | CHEMBL2205813 |
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Molecular formula | C21H25NO3 |
IUPAC name | 5-[2-(2,3-dimethoxyphenyl)ethyl]-5-azahexacyclo[5.4.1.02,6.03,10.04,8.09,12]dodecan-4-ol |
Molecular weight | 339.435 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 2.8 |
Synonyms | BDBM50401368 |
Inchi Key | FOTUXOOYRRRHFQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H25NO3/c1-24-12-5-3-4-9(20(12)25-2)6-7-22-19-15-10-8-11-14-13(10)16(19)18(14)21(22,23)17(11)15/h3-5,10-11,13-19,23H,6-8H2,1-2H3 |
PubChem CID | 71463061 |
ChEMBL | CHEMBL2205813 |
IUPHAR | N/A |
BindingDB | 50401368 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 4347.0 nM | PMID22959245 | BindingDB,ChEMBL |
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