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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor 1a
ghrelin receptor
GH-releasing peptide receptor
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL270790
Molecular formulaC23H26FN3O3S2
IUPAC nameN-[5-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl]-2-fluoro-4-thiophen-2-ylbenzenesulfonamide
Molecular weight475.597
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP4.2
SynonymsSCHEMBL4804237
Inchi KeyAMRSNVKLFBUABO-IYBDPMFKSA-N
Inchi IDInChI=1S/C23H26FN3O3S2/c1-15-13-27(14-16(2)25-15)18-7-8-21(30-3)20(12-18)26-32(28,29)23-9-6-17(11-19(23)24)22-5-4-10-31-22/h4-12,15-16,25-26H,13-14H2,1-3H3/t15-,16+
PubChem CID44452932
ChEMBLCHEMBL270790
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501.995 nMPMID18316188ChEMBL
Intrinsic activity0.9 -PMID18316188ChEMBL

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