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GLASS

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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL158671
Molecular formula	C21H15FN2
IUPAC name	4-[3-(4-fluorophenyl)-5-phenyl-1H-pyrrol-2-yl]pyridine
Molecular weight	314.363
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.7
Synonyms	2-(4-Pyridinyl)-3-(4-fluorophenyl)-5-phenyl-1H-pyrrole BDBM50075762 4-[3-(4-Fluoro-phenyl)-5-phenyl-1H-pyrrol-2-yl]-pyridine
Inchi Key	GFHBMDLZPIDPHI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H15FN2/c22-18-8-6-15(7-9-18)19-14-20(16-4-2-1-3-5-16)24-21(19)17-10-12-23-13-11-17/h1-14,24H
PubChem CID	44372405
ChEMBL	CHEMBL158671
IUPHAR	N/A
BindingDB	50075762
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	390.0 nM	PMID10201821	BindingDB,ChEMBL
IC50	801.68 nM	Med Chem Res, (2013) None:None:1	ChEMBL
IC50	802.0 nM	N/A	BindingDB

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