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GLASS

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GPCR

Name	Metabotropic glutamate receptor 2
Species	Rattus norvegicus (Rat)
Gene	Grm2
Synonym	glutamate receptor GPRC1B metabotropic glutamate receptor 2 mGlu2 receptor mGluR2
Disease	N/A for non-human GPCRs
Length	872
Amino acid sequence	MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProt	P31421
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2851
IUPHAR	290
DrugBank	N/A

Ligand

Name	CHEMBL333519
Molecular formula	C8H10FNO4
IUPAC name	(1R,2S,5R,6R)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Molecular weight	203.169
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	-3.0
Synonyms	BDBM50094842 (+)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid SCHEMBL1088473 AFBD Bicyclo[3.1.0]hexane-2,6-dicarboxylicacid, 2-amino-6-fluoro-, (1R,2S,5R,6R)- (+/-)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid CTK1A0543 260353-65-9 AKOS027403822 (-)-2-Amino-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid DTXSID10431169 [ Show all ]
Inchi Key	GLDRBCJXSGSXEU-JKBXLQNXSA-N
Inchi ID	InChI=1S/C8H10FNO4/c9-8(6(13)14)3-1-2-7(10,4(3)8)5(11)12/h3-4H,1-2,10H2,(H,11,12)(H,13,14)/t3-,4-,7+,8-/m1/s1
PubChem CID	9815617
ChEMBL	CHEMBL333519
IUPHAR	N/A
BindingDB	50094842
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<100000.0 nM	PMID11123999	ChEMBL
EC50	16.6 nM	PMID11123999	ChEMBL
EC50	34.2 nM	PMID11123999	ChEMBL
EC50	1120.0 nM	PMID11123999	ChEMBL
Ki	22.5 nM	PMID11123999	ChEMBL

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